Translational Biomedical Research Scientist
4 weeks ago
Unlock your potential in a premier academic medical center located in the heart of Richmond, Virginia. As a translational biomedical research scientist at Virginia Commonwealth University (VCU) School of Medicine, you will be part of a dynamic team exploring the translational application of improved CRISPR/Cas genome editors and developing innovative target cell-specific gene delivery in vivo.
Focusing on T cells and microglia, you will examine the efficacy of target cell-specific AAV, nanoparticle, or lentivirus-like particle delivery of CRISPR/Cas genome editors to combat infectious diseases such as HIV/AIDS (NeuroHIV) and new emerging viruses. Our research projects are NIH funded, and we have established advantageous novel animal models, human induced pluripotent stem cells (iPSC)-derived microglia-containing cerebral organoids, and CRISPR/Cas-mediated gene/cell therapy platform.
The major lab techniques involve molecular cloning, RNA interference, CRISPR/Cas genome editing, viral and non-viral gene delivery, library screening, neural stem cell culture, ES/iPSC and organoid culture, conditional transgenic or knockout mouse technologies, stereostatic microinjection, cell-based functional assays, in vitro transcription, mRNA stability, protein engineering, protein arrays, co-immunoprecipitation and Western blot, RT-PCR, HCR-fish, multi-labeled immunohistochemistry, and confocal imaging analysis, whole genome sequencing, bulk and single-cell RNA sequencing, and bioinformatics.
Core Responsibilities Include:
- Molecular cloning, gene editing, and viral gene delivery
- Cell culture and cell-based functional assays
- Immunohistochemistry and confocal image analysis
- Animal handling and neurobehavioral test
- The writing of manuscripts and grants as well as the mentoring of undergraduate and graduate students in PI's lab
Required Qualifications:
- PhD, and/or MD, in the field of biomedicine, molecular/cellular biology, and neuroscience
- Must have a demonstrated commitment to fostering diversity and inclusion in past experiences or a commitment to do so as a faculty member at VCU
Preferred Qualifications:
- Experience in CRISPR/Cas gene editing, viral packaging, and gene therapy
This is a restricted position with no set end date and continued employment is dependent upon project need, availability of funding, and performance. We continuously strive for our workplace and learning environment to reflect the demographic and social milieu of the communities we serve. All qualified applicants are encouraged to apply.
Estimated salary range is $50,000-$60,000.
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