Senior Research Scientist: Molecular Pharmacology and Toxicology

1 month ago


Richmond, California, United States Commonwealth of Virginia Full time
Cancer Research Opportunities

The Department of Pharmacology and Toxicology at VCU School of Medicine is seeking a highly motivated Research Assistant Professor to join the laboratory of Dr. Said Sebti at the NCI designated Massey Cancer Center. The research focus is to understand how normal cells become malignant and to translate such fundamental knowledge to the clinic.

Research Projects

1. Understanding the mechanism of mutant KRAS addiction and developing drugs to thwart mutant KRAS-driven cancers.
2. Identifying small molecules that bind KRAS and investigating the mechanism by which they block oncogenesis.
3. Identifying kinases that are synthetically lethal with mutant KRAS.
4. Identifying cell surface proteins specifically expressed on human cancers that are addicted to mutant KRAS, and developing therapeutic strategies based on these discoveries.
5. Developing dual FTase and GGTase-1 inhibitors as novel anti-cancer drugs targeting human tumors that harbor mutant KRAS.

Responsibilities

1. Conduct cancer research activities aligned with MCC vision and mission.
2. Submit and obtain peer-reviewed grants preferably R-type grants from NCI.
3. Publish manuscripts in high-impact journals.
4. Work closely with Dr. Sebti to harness intellectual talent and scientific resources of VCU to solve the nation's cancer problem.
5. Support the department with teaching responsibilities, including team-teaching medical and graduate levels courses.
6. Train and mentor graduate students seeking M.S. and Ph.D. degrees.
7. Serve as a member of departmental as well as university-wide service committees.

Qualifications

1. Ph.D. in Cancer Molecular Biology, Biochemistry, Cancer Cell Biology, Drug Discovery, or Pharmacology.
2. Experience in cancer research, particularly in Ras signal transduction pathways.
3. Ability to maintain detailed documentation through electronic and notebook means.
4. Demonstrated creativity, high motivation, solid communication skills, and experience in writing progress reports and manuscripts for peer-reviewed publications.
5. Extensive publication record in multi-disciplinary fields.
6. Commitment to diversity or a commitment to do so as a faculty member at VCU.
7. Experience working in a matrix environment within academic medicine, collaboration with multidisciplinary teams, proven trainee and faculty mentorship skills, and experience working closely with chemists, structural biologists, and clinical researchers.
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