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Engineer / Senior Process Engineer (Tech Ops MSAT)

1 month ago

Watertown, United States Abata Therapeutics Full time
About us:

Abata has a big vision focused on translating the biology of regulatory T cells (Tregs) into transformational medicines for patients, particularly in severe autoimmune and inflammatory diseases with inadequate or no therapeutic options. While cell therapies represent a significant advancement in treating human disease, they have not yet been rigorously evaluated and developed for the treatment of autoimmune and inflammatory diseases. The company believes that by engineering Tregs for targeted activation only at the site of disease, enabling a robust, durable response, while avoiding systemic immune suppression, they can revolutionize the treatment of these challenging chronic diseases.

Our work is transformative which is why we hire the best, brightest, and most importantly...kind people. Being kind is not just a personality trait we look for, it's a core value, embedded in the way we work and how we shape your experience at Abata Therapeutics. One of the most important aspects of your experience at Abata is how you develop and grow with the company. Our culture of learning and growth enables everyone to do their best work and contribute to fulfilling our mission.

The Role:

As a Senior Process Engineer, you will provide cross-functional leadership and technical oversight at our contract manufacturing site. You will serve as the technical person-in-plant, offering on-the-floor support to ensure manufacturing excellence. Your responsibilities include managing technology transfers and manufacturing operations for all new and existing Cell Therapy Manufacturing assets. Additionally, you will develop process trending tools, provide process improvement recommendations, and play a key role in the lifecycle management of Abata Therapeutics's cell therapy products.

What you'll do
  • Serve as the technical representative at the contract manufacturing site, offering on-the-floor technical assistance to optimize manufacturing operations (Person-in-Plant).
  • Collaborate with cross-functional teams, including the CDMO joint project team, Abata Process and Analytical Development, Quality Assurance, Quality Control, and Regulatory to ensure the efficient execution of clinical manufacturing operations and the transfer of new assets and process enhancements within agreed timelines to support business objectives.
  • Review GMP-executed manufacturing batch records
  • Support Deviation Management, CAPA, and Change control to ensure timely batch release.
  • Manage the drafting of technical documents, such as master batch records and components of technology transfer packages
  • Function as a manufacturing subject matter expert within the MSAT organization
  • Collect and analyze manufacturing data to identify areas for improvement
  • Develop and deliver training materials to ensure the operational and scientific training of all employees involved with new processes and product introductions.
What we're looking for
  • BS/BA in Chemical, Biological or Biomedical Engineering with 8+ yrs or MSc with 6+ yrs or equivalent combination of education and work experience
  • 2+ years of experience in cell therapy manufacturing
  • Proven experience with process technical transfer, technical operations, and lifecycle management
  • Detail-oriented with excellent problem-solving, technical writing and verbal communication skills
  • Ability to effectively work in multidisciplinary teams, meet deadlines, and prioritize multiple projects
  • Aptitude for working in a self-driven, performance/results-oriented, fast-paced matrix environment
What will separate you from the crowd
  • Experience with cell therapy manufacturing processes and equipment, including T cell isolation, cell sorting, lentiviral transduction, gene editing, expansion in bioreactors, cell harvest, and cryopreservation
  • Well-versed with cGMP requirements and working in a regulated environment
  • Prior experience supporting tech transfers to external partners
  • Knowledge of R, Python, JMP, Spotfire
What you should know
  • Local travel up to 50% of the time (currently, Waltham to Watertown)
  • Work in a grade B space, including sterile gowning
  • Some weekend work
  • This position requires handling of human blood products


We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

This is an on-site position based in the Watertown, MA office and the employee will be required to work in the office on a regular basis.

Abata Therapeutics will require compliance with our COVID- 19 vaccination policy. Please Review our conditions of employment.

Conditions of employment:

All current Abata employees have received the first two rounds of vaccinations against COVID-19. Vaccination status must be confirmed prior to any new hires joining the team. Up to date vaccination is strongly encouraged for every employee who intends to work onsite at our office and lab facility. Should an employee choose not to receive the vaccine, we will seek to understand the facts of their individual circumstance and determine if an appropriate work arrangement can be achieved.