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Senior Research Scientist II

1 month ago


Trenton, United States J-STAR Research Full time

We now have exciting opportunities for Senior Research Scientists to join our vibrant and growing group, with the successful candidates joining a cutting edge CRO with access to gloveboxes, high throughput experimentation, in-situ reaction monitoring tools and state of the art analytical equipment. The primary role responsibility is to perform scale-up of flow chemical reactions, process development, optimization, scale-up and manufacturing in support of J-Star’s Enabling Technologies projects. The incumbent should provide the expertise in the scaleup requirements of flow chemical processes and manufacturing process development. Prerequisites Experience within the pharmaceutical/biotechnology industry or CDMO industry is required. Experience in both is desirable, but not required. PhD in Process Engineering or Chemical Engineering with a minimum of 2 years of industrial experience or a MS with a minimum of 8 years industrial experience is required. Responsibilities Conduct chemical engineering R&D for clients as an individual contributor, which includes, but is not limited to, scale-up of chemical reactions in flow and batch mode, conduct experiments to investigate effects of mixing and heat and mass transfer, reaction modeling, statistics & DoE, enabling technologies. This will include R&D under c-GLP and potentially under c-GMP conditions. Contribute to the adoption and operation of new flow technology. Contribute to the expansion of flow chemistry from R&D to process scale up, flow-photochemistry and multiphasic reactions. Contribute to the development of safe, timely and efficient chemical processes by using established, new and/or novel chemical technologies and processes. Contribute chemical engineering methodology to process and/or catalysis development, optimization and problem solving. Maintain an uncompromising focus on quality, documentation, confidentiality, and scientific execution. Adhere to R&D, processing schedules and deliverables. Contribute to scientific and technical discussions with co-workers and clients to plan, execute, resolve issues and problem solve. Contribute to scientific and technical discussions with co-workers and clients to plan, execute, resolve issues and problem solve. Communicate candidly, clearly and timely with clients, management and peers. Participate in weekly client updates as needed, prepare weekly reports, contribute to campaign reports and participate in process chemistry technology transfer. Follow all company, site and laboratory Environmental, Health and Safety (EHS)-related protocols, processes, guidelines and SOPs. Actively participate in EHS discussions with peers and management for continuous improvement of EHS practices. Maintain a clean and well-organized hood, bench, glovebox and common work area that is free of clutter, excess chemicals/samples. Qualifications Experienced in the fundamental principle of chemical engineering related to scale-up of flow and batch chemistry, specifically reaction kinetics, reactor design, chemical thermodynamics, heat and mass transport, engineering statistics. Experienced using DynoChem, Reaction Lab, MixIt or other modeling software. Experienced with in-situ reaction monitoring like hydrogen uptake kinetics, ReactIR or Raman. Knowledge of statistics and Design of Experiment principles using tools like JMP or Design Expert. A good foundational understanding of synthetic organic chemistry. Proven track record meeting aggressive targets as related to safe, timely and successful synthetic organic chemistry projects. Knowledge and experience base of working in a c-GMP environment is preferable, but not required Excellent written, verbal and presentation skills. Experience in small molecule drug development is preferable, but not required. Track record of scientific success as measured by publications and presentations. Ability to prioritize and manage numerous activities simultaneously. Ability to interact in an effective and appropriate manner with diverse population sets. Experience in working on and positively contributing to scientific teams. Ability to perform the physical requirements of the position. Proficient in Microsoft®Office™ applications. Reporting Relationship Reports to a Vice President, Director, Associate Director or Sr. Process Chemist (Principal Scientist) Primary Location: New Jersey, USA Employee Status: Individual Contributor Job Type: Full Time/Salaried #J-18808-Ljbffr