Director of Shared Antigen Cancer Vaccines Research
4 weeks ago
Moderna is seeking a highly skilled and strategic Director of Shared Antigen Cancer Vaccines Research to join our Cancer Vaccines Research team, focusing on early pipeline programs. The Director will lead the early discovery and preclinical validation of shared antigen cancer vaccine candidates, overseeing the translation of innovative scientific concepts into actionable clinical programs in close collaboration with a diverse array of internal teams.
This role requires a scientific leader who can balance scientific innovation, rigorous scientific execution, and oversight to guide teams through the complex processes of early discovery, preclinical validation, and regulatory preparation. The Director will closely collaborate with clinicians to translate research findings into actionable clinical strategies, work with translational experts to develop robust biomarker plans, and collaborate with CMC teams to ensure the timely manufacture of new vaccine candidates.
Key Responsibilities
• Provide leadership and direction for early discovery programs, overseeing a team of scientists dedicated to evaluating new targets, optimizing immunogen designs, demonstrating function in biochemical, cell-based, and preclinical models.
• Provide deep expertise in immuno-oncology, with a proven ability to characterize mechanisms of action (MOA) and mechanisms of resistance (MOR).
• Contribute to envisioning, drafting, and critical review of regulatory documents, including INDs, supporting the advancement of early-stage clinical assets from the fast-emerging portfolio.
• Lead, mentor, and develop a high-performing team of scientists, fostering a culture of innovation, collaboration, and scientific excellence.
• Create and oversee an efficient research strategy, including milestone-driven, risk-mitigated experimental strategies.
• Establish group goals, associated budgets, and set timelines for deliverables.
• Build resilient, cross-functional relationships across the research and development organizations to enable robust thought partnership, execution of rigorous science, and efficient clinical development of our fast-expanding pipeline of medicines.
• Represent Moderna at scientific conferences and contribute to high-impact publications.
Requirements
• PhD or MD/PhD in immunology, oncology, molecular biology, or a related field.
• 10+ years of experience in cancer immunotherapy and/or vaccine development in industrial settings.
• Proven leadership experience, with a history of leading successful research teams and early-stage discovery programs through IND filing.
• Technical expertise to enable rigorous oversight of the generation and analysis of preclinical samples, such as with genomic profiling, bulk and single-cell RNA sequencing, multi-parameter flow/CyTOF panels/spectral flow cytometry, and MS-immunopeptidomics data.
• Evidence of leveraging deep technical expertise in Immuno-Oncology to evaluate Mechanisms of Action and Resistance MOA/MOR.
• Experience in drafting and reviewing regulatory filings and working cross-functionally with clinical and regulatory teams.
• Demonstrated ability to effectively manage and develop direct reports.
• Ability to manage multiple projects in a fast-paced environment with aggressive timelines.
• Excellent interpersonal and communication skills, with a collaborative mindset and the ability to build strong relationships with internal and external stakeholders.
• A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative.
• A passion for innovation and the mission of developing transformative medicines in the fight against cancer.
About Moderna
Moderna is a leading biotechnology company that is pioneering the use of mRNA technology to develop transformative medicines. We are committed to making a meaningful impact on the lives of patients and their families. Our team is passionate about innovation, collaboration, and scientific excellence, and we are seeking a talented individual to join our team as a Director of Shared Antigen Cancer Vaccines Research.
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Cambridge, Massachusetts, United States Moderna Full timeAbout the RoleModerna is seeking a highly skilled and strategic Director of Shared Antigen Cancer Vaccines Research to join our Cancer Vaccines Research team, focusing on early pipeline programs.Key ResponsibilitiesLead the early discovery and preclinical validation of shared antigen cancer vaccine candidatesOversee the translation of innovative scientific...
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