Scientist, Antibody Discovery

3 weeks ago


san francisco, United States SciPro Full time

**MULTIPLE OPENINGS**


Scientist - Antibody Discovery

100% onsite in South San Francisco, CA

6-12mth contract (with long term contracting opportunity / potential future conversion)


Seeking a Scientist/Sr with background in molecular biology and protein biochemistry to work closely with members of the Antibody Discovery Team to support Large Molecule therapeutic programs.


RESPONSIBILITIES

  • Design strategies and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage display
  • Generate antibody fragment libraries for antibody discovery and engineering, perform HT binding screens (ELISA and multi-plex flow cytometry) and sequence analysis to generate hits
  • Rank-order clones by affinity, in vitro potency, and early developability assessment
  • Execute sequence optimization of lead antibodies to improve developability and binding affinity
  • Design and clone constructs for mAbs, bispecific, and multi-specific antibodies for recombinant antibody production
  • Support NGS-based antibody discovery workflow
  • Present data and updates to management and project teams
  • Follow good documentation practice including maintaining good record keeping in Electronic Notebooks


REQUIRED QUALIFICATIONS AND BACKGROUND

  • PhD in Biochemistry, Biomedical/Chemical Engineering, Immunology, or related field with minimum of 2 years of post-graduate experience (preferably in industry), MS with 8+ years of research experience, BS with 10+ years of research experience in antibody or protein engineering
  • Significant experience in antibody discovery and protein engineering by using single B cell cloning, hybridoma, or phage/yeast display techniques
  • Strong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteins


ADDITIONAL PREFERENCES

  • Experience in single domain antibodies, multi-specific antibody engineering, Fc engineering, antibody drug conjugates, naïve phage or yeast display library design
  • Experience in NGS analysis for antibody discovery and engineering
  • Significant contributions to successful biologics drug discovery programs in industry


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