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Research Scientist Protein Sciences
1 month ago
At EvolutionaryScale, we are revolutionizing the field of biology by harnessing the power of artificial intelligence. Our mission is to unlock the complexities of biology for the benefit of human health and society. We are committed to pushing the boundaries of what AI can achieve in biological discovery, and we are seeking a highly motivated Research Scientist I-Protein Sciences to join our team.
Job SummaryWe are seeking a Research Scientist I-Protein Sciences to support our AI-guided protein design efforts. The ideal candidate will have experience in protein engineering, molecular biology, and biochemistry, with a focus on protein expression, purification, and binding characterization. The successful candidate will play a key role in advancing protein design using artificial intelligence, contributing to groundbreaking discoveries in the field.
Key Responsibilities- Perform molecular biology techniques, including cloning and construct design, to support protein engineering projects.
- Conduct protein expression and purification in both prokaryotic and eukaryotic systems.
- Characterize protein interactions and binding using biophysical techniques such as Biolayer Interferometry (BLI) or Surface Plasmon Resonance (SPR).
- Develop rapid and high-throughput selection or screening techniques to support AI/ML protein design and validation.
- Develop accurate and informative assays for biophysical characterization of AI-designed proteins.
- Coordinate experimental design and execution internally and externally with CROs.
- Serve as a thought leader in biological applications of AI/ML protein design.
- Present data to key stakeholders.
- Collaborate with cross-functional teams to generate, analyze, and interpret experimental data.
- Prepare and write SOPs, technical reports, and research documentation.
- Process and organize experimental data, ensuring accuracy and reproducibility.
- Assist in assay development and optimization, including ELISA and protein stability assays.
- Maintain electronic laboratory notebooks and ensure compliance with internal and external guidelines.
- Practical knowledge of protein engineering, cloning and protein expression systems.
- Experience with protein purification by affinity, ion exchange and size exclusion chromatography.
- Experience with mammalian expression for the production of antibodies or recombinant proteins.
- Experience with display technologies such as phage, yeast, or mammalian display.
- Familiarity with techniques for measuring protein stability or aggregation.
- Experience with ELISA and protein stability assays.
- Experience with experimental structural biology is a plus.
- Hands-on experience with NGS data analysis is a plus.
- Proficiency with Python data analysis is a plus.
- PhD degree in Biochemistry, Biophysics, Molecular Biology, Cell Biology, Bioengineering, or a related field with 1-2 years of industry experience.
- Strong proficiency in cloning, protein expression, purification, and binding characterization techniques.
- Demonstrated ability to work independently and as part of a team.
- Strong skills in data processing, record keeping, and writing reports.
- Experience leading a team of junior scientists is a plus.
- Experience with structural biology, computational protein design, bioinformatics is a plus.
We offer competitive compensation packages in line with industry standards for the San Francisco area. Depending on experience and qualifications, the salary range for this position is $140,000-$170,000.
