Scientist | PhD, Protein Chemist

2 weeks ago

San Diego, United States Abilita Therapeutics, Inc. Full time

At Two Bear Capital, we believe in supporting our companies to scale their workforce and in bringing onboard the best talent in the marketplace. We look forward to working with you during the interview process for Abilita Therapeutics new Scientist position, based in San Diego*.


Company Overview:

Abilita Therapeutics is an innovation-driven biotechnology start-up company focused on enabling the discovery and development of drugs targeting undruggable membrane proteins, including G Protein-Coupled Receptors (GPCRs), transporters and ion channels. Dive deeper into our vision at www.abilitatx.com.

Position:

We are in search of a highly motivated and talented Scientist with a background in membrane protein expression, purification and analysis.


Qualifications:

  • PhD degree in biochemistry, structural biology or molecular biology.
  • At least 10 years hands-on experience in protein purification and molecular biology in combined academic + industry setting.
  • Prior experience with cryo-EM and membrane proteins purification such as GPCRs, ion channels, or transporters is strongly preferred.
  • Experience with protein purification/analysis methods such as SEC, IMAC, ion exchange chromatography, dialysis, SDS-PAGE is required.
  • Proficiency with basic molecular biology techniques (PCR, restriction enzymes and/or ligation-independent methods) as well as more advanced methods like Golden gate, Gibson cloning.
  • Demonstrated capabilities to independently design, implement, and troubleshoot experimental work in a laboratory.
  • Strong communication and presentation skills.


Key Responsibilities:

  • Lead the design, execution, and troubleshooting of complex, small and large-scale purification strategies for recombinant membrane and soluble proteins, focusing on overcoming technical challenges and optimizing protocols for novel targets.
  • Independently perform biophysical characterization of purified proteins using multiple methods and instruments (FPLC, HPLC, DLS, DSF, etc).
  • Refine and optimize purification protocols, while addressing challenges that arise.
  • Independently design and execute DNA cloning, transformation of various microorganisms.
  • Ability to work in a highly interactive and multidisciplinary team environment.
  • Operate and maintain the relevant equipment.
  • Manage parallel processing of extensive sample sets.
  • Support the organization by producing high-quality and reliable data.
  • Maintain close collaborative interactions with colleagues within the research group, and regularly communicate progress to the team or supervisors.
  • Uphold our corporate values of integrity, open communication and collaboration.


*possible hybrid opportunity

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