Research Associate II/Sr Research Associate, Downstream Production
2 months ago
Downstream Production & Process Development
Company Overview
Repertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer, autoimmune disease and infectious disease. The company was founded on the belief that understanding the repertoire of T cell receptor (TCR)-antigen immune synapses that maintain health and drive disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODETM platform, which allows in-depth characterization of TCR-antigen pairs, and the ability to deploy this information in the form of novel targeted immune medicines to fundamentally reprogram the immune system to kill tumors or induce immune homeostasis.
From its sites in Cambridge, Massachusetts and Zurich, Switzerland, Repertoire’s team is advancing a pipeline of DECODE-enabled immune medicines, such as TCR bispecifics and mRNA cancer vaccines for treatment of solid tumors and mRNA tolerizing vaccines for treatment of autoimmune diseases.
Repertoire was founded by Flagship Pioneering and is supported by a strong investor base. In addition, the company recently entered into a strategic partnership with Bristol Myers Squibb to develop tolerizing vaccines for up to three autoimmune diseases.
On Site in Cambridge 5 days per week
Role Overview
We are seeking a passionate Research Associate II/Senior RA to support downstream production and process development of TCR bispecifics and MHC proteins on our Protein Engineering and Molecular Sciences team. The ideal candidate will have hands-on experience in protein purification, with preferred experience refolding proteins from inclusion bodies and/or with chemical modification of proteins. The incumbent will work at the bench to refold, purify, modify and QC TCR bispecifics and MHC proteins using biochemical methods such as ELISA, SDS-PAGE, Western, Octet and analytical methods such as HPLC. The candidate will be responsible for protein production, data analysis and presenting data to their supervisor and to the team in an effective and timely manner. Interested candidates should have strong organizational, interpersonal, verbal, and written communication skills that will enable them to integrate with our highly cross-functional team.
Key Responsibilities
- Optimize protein refolding conditions from inclusion bodies.
- Develop robust processes for protein purification from mammalian expression supernatant or from refolding, using Immobilized metal affinity, ion-exchange, and size exclusion chromatography.
- Execute enzymatic and chemical protein modification protocols.
- Generate purified and modified proteins at the 5-50 mg scale and maintain inventory.
- Characterize recombinant proteins using SDS-PAGE, Western blot, protein quantitation, HPLC, ELISA, Octet and other biochemical/biophysical assays to determine protein purity and function.
- Capture primary data, establish and maintain SOPs, and document work as required in Electronic Laboratory Notebook (ELN), maintaining up to date records.
- Present data routinely to the Protein Sciences group and other multidisciplinary groups.
Qualifications/Experience
- BS/MS in Biochemistry, Biology, Bioengineering, Immunology, or a similar field.
- 2+ years of academic or biotech/pharma laboratory experience.
- Experience with FPLC systems and with affinity, IEX and SEC protein purification methods is desirable.
- Experience with protein refolding from inclusion bodies and/or protein modification is a plus.
- Strong organizational and communication skills along with excellent attention to details.
- Enjoys working in a collaborative, fast-paced and quickly changing environment.
Repertoire is committed towards social responsibility and developing an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce. We believe in actively pursuing equity in all facets of the work experience at Repertoire. We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.
Repertoire is proud to be an Equal Opportunity Employer.
Recruitment & Staffing Agencies: Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire’s internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.
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