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Research Associate II/Sr. Research Associate, QC
3 months ago
Repertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer, autoimmune disease and infectious disease. The company was founded on the belief that understanding the repertoire of T cell receptor (TCR)-antigen immune synapses that maintain health and drive disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODETM platform, which allows in-depth characterization of TCR-antigen pairs, and the ability to deploy this information in the form of novel targeted immune medicines to fundamentally reprogram the immune system to kill tumors or induce immune homeostasis.
From its sites in Cambridge, Massachusetts and Zurich, Switzerland, Repertoire’s team is advancing a pipeline of DECODE-enabled immune medicines, such as TCR bispecifics and mRNA cancer vaccines for treatment of solid tumors and mRNA tolerizing vaccines for treatment of autoimmune diseases.
Repertoire was founded by Flagship Pioneering and is supported by a strong investor base. In addition, the company recently entered into a strategic partnership with Bristol Myers Squibb to develop tolerizing vaccines for up to three autoimmune diseases.
On Site in Cambridge 5 Days per Week
Role Overview
We are seeking a passionate Research Associate II/Senior Research Associate to work in the Protein Engineering and Molecular Sciences Team to support analytical and biophysical QC of TCR bispecifics and MHC proteins as well as development of analytical assays for tech transfer to manufacturing. The ideal candidate will have hands-on experience in methods such as size exclusion HPLC, SDS-PAGE, DSF, ELISA and/or Octet/SPR. The selected candidate will work at the bench to QC TCR bispecifics and MHC proteins, conduct stability/developability assessments to prioritize therapeutic leads, and develop robust assays for tech transfer to manufacturing partners. This incumebt will be responsible for developing SOPs, generating biochemical and biophysical data, data analysis and presenting data to their manager and to the team in an effective and timely manner. Interested candidates should have strong organizational, interpersonal, verbal, and written communication skills that will enable them to integrate with our highly cross-functional team.
Key Responsibilities
- Analytical and biophysical QC of protein batches (analytical SEC, PAGE, DSF, Octet/SPR, ELISA).
- Develop and document robust analytical assays for tech transfer to manufacturing partners.
- Conduct comparability, developability and accelerated stability assessments of lead therapeutic molecules.
- Capture primary data, establish and maintain SOPs, and document work as required in Electronic Laboratory Notebook (ELN), maintaining up to date records.
- Present data routinely to the Protein Sciences group and other multidisciplinary groups.
- BS/MS in Biochemistry, Biology, Bioengineering, Immunology, or a similar field.
- 2+ years of academic or biotech/pharma laboratory experience.
- Experience with HPLC systems and with biochemical assays such as ELISA, SDS-PAGE and DSF.
- Experience with Octet, SPR or flow cytometry a plus.
- Strong organizational and communication skills along with excellent attention to details.
- Enjoys working in a collaborative, fast-paced and quickly changing environment.
Repertoire is proud to be an Equal Opportunity Employer.
Recruitment & Staffing Agencies: Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire’s internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.
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