Research Associate/Senior Research Associate, RNA Process Development
1 month ago
Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.
The PositionWe are seeking a Research Associate or Senior Research Associate to join a team focused on process development of messenger RNA (mRNA) for Verve's novel CRISPR gene editing therapies. The ideal candidate will have interest in nucleic acid bioprocess development, chemical engineering, and problem solving. You will join a team conducting laboratory studies to support process development of mRNA as a drug substance. The ideal candidate will have process development industry experience and a desire to contribute to a team focused on establishing science-based manufacturing solutions for complex nucleic acid-based products.
Job Responsibilities- Plan and execute experiments at bench scale to support process development, scale up, and optimization of Verve's mRNA drug substance manufacturing process.
- Carefully execute a wide range of experiments to assist in establishing a science-based understanding of mRNA technology, process development and process scale-up.
- Perform routine analytics to support understanding of RNA technology and processes including but not limited to fluorescence, HPLC and ELISA based techniques.
- Opportunity to collaborate with cross-functional analytical development, tech transfer, external manufacturing as well as facility and operations colleagues.
- Write protocols, perform experiments, organize and analyze data, interpret results, record experiments in an electronic lab notebook, and summarize work in presentations and technical reports.
- Maintain a safe and high performing laboratory by ordering supplies, making buffers and reagents, caring for laboratory equipment and supporting continuous improvement initiatives related to lab operations.
- Other duties as assigned.
- B.S or M.S. in biological sciences, chemistry, or biomedical/chemical engineering, with 0-5 years of relevant industry experience is preferred.
- Knowledge of nucleic acid and or biologics process development is preferred
- Experience in downstream process development is ideal
- Experience with practices and equipment used in process development of nucleic acids; including execution of preparative chromatography processes using an Akta Avant, and TFF is strongly preferred
- Knowledge of analytical methods commonly used for nucleic acid is preferred; including fluorescence, capillary gel electrophoresis, analytical HPLC and ELISA based techniques
- Attention to detail, critical analysis of data and troubleshooting abilities
- Good writing and communication skills; ability to understand and communicate scientific information
Don't check off every box in the requirements listed above? Please consider applying anyway. We want the best candidates for the job, and those candidates don't always meet 100% of the qualifications listed. At Verve, we are dedicated to building diverse and inclusive teams who embody the values we share: grit, spirit, drive, and passion. We look forward to learning more about your unique background.
EEO StatementVerve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
Recruitment & Staffing AgenciesVerve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.
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