Scientist / Senior Scientist - Discovery & Protein Sciences

3 weeks ago

Cambridge, Massachusetts, United States UCB Full time

Make your mark for patients

To strengthen our Discovery Sciences and Protein Sciences teams in our Boston hub in Cambridge, MA, USA, we are looking for a talented individual to fill the position of: Scientist or Senior Scientist. As (Senior) Scientist, you will contribute to a scientific team as protein biochemist and cellular biologist. You will generate key reagents and set up in vitro assays to support and accelerate UCB's AAV gene therapy platform, working in the laboratory, within project teams, and across functions to support drug discovery research at UCB.

Please note: We are interested in every qualified candidate who is eligible to work in the United States. However, we are not able to sponsor visas at any point for this role. This includes taking over sponsorship for an existing Visa.

You like to work in an environment where you can:

• Apply your scientific expertise to provide innovative approaches for expression and purification of highquality purified proteins across diverse protein classes (secreted, cytoplasmic and membrane proteins)

• Establish an in vitro assay platform to evaluate AAV transduction and contribute to analysis of in vivo samples.

• Collaborate with cross-functional teams to ensure project milestones and timelines are met.

You will contribute by:

• Expressing and purifying high quality recombinant cytosolic, secreted, membrane proteins and validating these proteins with quality control experiments such as HPLC and mass spectrometry.

• Designing and generating transient and stable cell lines for in vitro assays. Contributing to analysis of tissue samples for the evaluation of AAV or other viral transduction to support our pipeline of drug discovery projects.

• Actively participate in project teams by communicating experimental results and advising on best methods to generate protein reagents for downstream applications including but not limited to biophysical characterization, immunization, assay development, screening and hit identification.

Interested? For this position you'll need the following education, experience and skills:

Minimum Qualifications:

• PhD in related field (biochemistry, molecular & cellular biology, or biophysics) + 0-6years' experience, BS or MS 8-15years' experience (including industry experience of 1-2 years)

• Expertise in recombinant protein expression from mammalian cells and purification utilizing the AKTA platform and current knowledge of purification methods and protocols.

• Proficient in cell culture and cell imaging, such as stable cell line generation and maintenance, high content imaging or flow cytometry.

Preferred Qualifications:

• Familiarity with additional recombinant cell expression methods, such as insect cell expression, generation of virus, virus-like particles, and bacterial expression

• Foundational knowledge of cellular trafficking (such as: endocytosis, transcytosis, etc.)

• Experience with iPSCs, organoids or other complex in vitro models.


• Familiarity with drug discovery and appreciation of critical path activities and resource prioritization that support program progression.

Note: The level of this position will be adjusted to suit your experience and we will train you on additional methods as you grow in your role.

Salary Range: $96,480 to $126,630

Are you ready to 'go beyond' to create value and make your mark for patients? If this sounds like you, then we would love to hear from you

About us
UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are around 8,500 people in all four corners of the globe, inspired by patients and driven by science.

Why work with us?
At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equitable opportunities to do their best work. We 'go beyond' to create value for our patients, and always with a human focus, whether that's on our patients, our employees, or our planet. Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential.

As an Equal Opportunity Employer, we are open to all talent, and adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on US- for application to US based roles. Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.

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