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Investigator, Platform Chemistry
3 months ago
Posted Date: Jul
GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Drawing on the in-depth expertise of teams of multi-disciplinary scientists, we prioritize innovation in vaccines and specialty medicines to prevent and treat disease.
We are currently looking for a highly motivated organic chemist to join our Encoded Technologies team in Cambridge, MA. GSK is a leader in DNA-encoded library technology, enabling exploration of novel target biology and identification of qualified hits for drug discovery programs. The primary focus of this role is to support the design and synthesis of novel DNA-encoded libraries, to develop new on-DNA reactions, and to drive innovation in our platform. A successful applicant will have an excellent practical and theoretical understanding of synthetic organic chemistry and can design and execute high quality, thoughtful experiments, while making significant contributions both independently and as a member of a multidisciplinary team. Subject to approval of reasonable request, GSK is a modern employer and offers flexible working hours and conditions.
This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:
- Design and synthesize novel, high-quality DNA-encoded libraries within a team
- Develop and optimize new DNA compatible reactions that can be employed in the production of DNA-encoded libraries
- Drive innovation in our platform as part of our multidisciplinary team
- Communicate key results and enable data driven decision making
- Share in responsibilities to support general lab functions
- Contribute to writing and conceptual framework of publications, presentations and patents when appropriate
- Establish and maintain a detailed knowledge of literature related to areas of research
Success in GSK thrives on strong interpersonal and practical chemistry skills combined with a curious, inquisitive nature and a passion for science. You are equally passionate about developing yourself, developing new scientific methods, pushing the limits of innovation, and learning something new every day. You are an excellent team player, able to work with others both in the lab and the office as well as within matrix teams. You are independent and able to plan and execute your own workload and deliver results. Your science is conducted with integrity, safety, and to the highest standards. You pride yourself in your chemistry and enjoy science as much as we do.
Why you?
Basic Qualifications:
- PhD in Organic Chemistry or equivalent industrial experience.
- Experience with state-of-the-art synthetic chemistry techniques and excellent problem-solving skills.
- Experience in independent interpretation of data from experiments and using it to make meaningful conclusions/decisions.
Preferred Qualifications:
If you have the following characteristics, it would be a plus:
- Strong organizational skills with attention to detail and a focus on quality results.
- Self-motivated with an ability to work effectively in a collaborative environment.
- Excellent interpersonal and communication skills
- High learning agility and curiosity to learn and adopt new technologies.
- Courage to take on ambitious goals and move forward at pace.
- Ability to learn and grow through challenging work and willingness to give and receive constructive feedback as part of an effort to continuously improve.
- Scientific record demonstrating excellence in chemistry (e.g. peer reviewed publications, patents or presentations)
- Demonstrated ability to critically review and effectively communicate scientific data and to influence outside of core area of expertise.
- Familiarity of on-DNA reaction development and encoded library synthesis
- Experienced in one or more of the following areas: cheminformatics, programming, and machine learning.
- Working knowledge of parallel synthesis and/or high-throughput experimentation.
- An understanding of contemporary synthetic methods (photochemistry, electrochemistry, biocatalysis, C-H functionalization) in the context library-based synthesis applications.
For questions about the role or general information about GSK and the Encoded Technologies team, please reach out to
Melissa Grenier-Davies, Ph.D. (she/her)
Principal Investigator, Platform Chemistry, Encoded Technologies
For further information, please see the following references :
Clark et al. Design, Synthesis and Selection of DNA-Encoded Small-Molecule Libraries. Nat. Chem. Biol. 2009, 5, DOl:70.7038/nchembio.211
Arico-Muendel et al. From haystack to needle: finding value with DNA encoded library technology at GSK. MedChemComm 2076, 7, DOl:l0.1039/c6md00341A
Phelan et al. Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis. J. Am. Chem. Soc. 2079, 147, 8, DOI: 10.l021/jacs.9b00669
Csakai et al. Reaction development for DNA-encoded library technology: expanding the toolkit of on-DNA chemistry. Med. Chem. Rev. 2021, 56, l0.29200/acsmedchemrev-v56.chl7
Rowley et al. Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library. J. Med. Chem. 2024, 67,
l 0.1027/ acs.jmedchem.3c07562
#LI-GSK
Please visit GSK US Benefits Summary t o learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
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