![Mayo Clinic](https://media.trabajo.org/img/noimg.jpg)
Postdoctoral fellow – iPSC generation for modeling genetic disorders
1 month ago
The Systems Biology and Translational Medicine Laboratory directed by Akhilesh Pandey, M.D., Ph.D. at Mayo Clinic in Rochester, Minnesota, USA, works on basic and translational sciences with the goal of improving and individualizing medicine. We are looking for a motivated and driven molecular biologist with experience in creating and working with in vitro models of genetic disorders including induced pluripotent stem cells (iPSCs), cell models and organoids. Required qualifications include a doctoral degree in the above-mentioned areas with a demonstrated proficiency in tissue culture, generation of induced pluripotent stem cells (iPSCs), differentiation of iPSCs along various lineages and CRISPR-based gene editing. The successful candidate will work with a dynamic and interdisciplinary team of scientists.
Duties and roles
· Work with the PI for hypothesis development and experimental design
· Generate iPSCs from patient-derived primary cells
· Culture and characterize newly generated iPSC lines and differentiate them along various lineages based on needs
· Perform CRISPR-based gene editing and CRISPR-based screens
· Generate organoids from gene-edited cell lines and patient tissues
· Participate in discussions with the research group and presents in conferences/workshops
· Write scientific manuscripts and grant proposals
· Train and work with graduate students and other postdoctoral fellows
Qualification
Education requirements
Doctorate degree is required. Demonstrated significant, original, and creative contributions to a research or creative program or project.
Experience and skills
· Experience with generating iPSCs from primary patient-derived cells
· Experience with differentiation of iPSCs along various lineages such as neuronal cells, osteoblasts, hematopoietic cells, cardiomyocytes etc.
· Willingness to expand the work on additional cell types and systems
· In depth knowledge and experience with CRISPR screens and analysis
· Comfortable working independently and as part of a team
· Ability to track and execute multiple projects at once
· A track record of publications in the above-mentioned areas
· Excellent written and oral communication skills are essential.
About the group
The position to be filled will be in the Systems Biology and Translational Medicine Laboratory at Mayo Clinic, Rochester, Minnesota, USA, led by Dr. Akhilesh Pandey. We are an enthusiastic and multi-disciplinary team of researchers who include mass spectrometrists, molecular biologists, computational biologists, physician-scientists and pathologists. We apply different Omics technologies to solve problems in biology, cancer and genetic diseases. We employ next-generation sequencing technologies including long-read sequencing towards whole genome, exome and transcriptome analysis. We use advanced mass spectrometry platforms (among others) to study proteomics, lipidomics and metabolomics, tailoring our methods to various problems as needed, e.g., to study protein post-translational modifications, protein-protein interactions and perform targeted analyses.
Among the focus areas of the lab are genetic disorders and cancers, with the aim of discovering novel diagnostic and therapeutic targets as well as to carry out functional studies to understand the molecular basis of these disorders. We have been deploying mass spectrometry-based and other methods for multi-omic characterization of genetic disorders including congenital disorders of glycosylation (CDGs), mitochondrial disorders, lysosomal storage disorders and disorders of lipid metabolism. Beyond molecular characterization, we also identify and validate novel biomarkers. We combine discovery and targeted mass spectrometry approaches to develop assays for molecules altered in metabolic disorders, e.g., ceramides, sphingolipids, proteins, peptides and glycopeptides.
Application procedure
Qualified candidates should e-mail with their CV and a brief statement of interest
Company
Mayo Clinic
Location
200 First Street
Rochester, Minnesota
USA
Website
-
RTP-Research Fellow-PC-Setayesh
1 month ago
Rochester, New York, United States Mayo Clinic Full timeWhy Mayo ClinicMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future....
-
Rochester, New York, United States Mayo Clinic Full timeWhy Mayo ClinicMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future....
-
Automotive Antenna Measurement Research Fellow
53 minutes ago
Rochester, New York, United States Oakland University Full timeJob SummaryThe Postdoctoral Research Fellow will work under the supervision of Prof. Daniel N. Aloi, Director of the Applied EMAG and Wireless Lab, to conduct research in the area of automotive spherical near-field antenna measurements.Key ResponsibilitiesConduct research experiments and simulations in the field of automotive antenna measurement...
-
Research Fellow
4 weeks ago
Rochester, New York, United States Mayo Clinic Full timeWhy Mayo ClinicMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans ) – to take care of you and your family, now and in the...
-
Rochester, New York, United States Oakland University Full timeBecome a key member of our research team as a Postdoctoral Research AssociateThe Applied EMAG and Wireless Lab, under the guidance of Prof. Daniel N. Aloi, is on the lookout for a Postdoctoral Research Associate to engage in pioneering research focused on automotive spherical near-field antenna measurement techniques. This role encompasses:Executing...
-
Camp Counselor
2 hours ago
Rochester, New York, United States Oakland University Full timeJob SummaryOakland University is seeking a Summer Camp Staff member to support individuals with Autism Spectrum Disorders at our summer camps. As a Summer Camp Staff member, you will be responsible for ensuring the safety and engagement of campers with autism.Key ResponsibilitiesWork as a team with lead teachers, administrators, and practicum students to...
-
Rochester, New York, United States Mayo Full timeMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. With a 73,000-person workforce, Mayo Clinic cares for more than 1.3 million people each year with serious or complex illnesses from all 50 U.S. states and 130 countries. Mayo Clinic is the largest not-for-profit, multidisciplinary academic...
-
Faculty Position in AI
4 weeks ago
Rochester, New York, United States Mayo Full timeMayo Clinic's Department of Artificial Intelligence and Informatics is searching for new faculty members to join our team Positions are available at all Mayo Clinic locations (Jacksonville, FL; Rochester, MN; and Scottsdale, AZ). The ideal candidate will have a demonstrated history of extramural funding including NIH or NIH-equivalent and a strong promise...
-
Faculty Position in Neurology Research
2 months ago
Rochester, New York, United States Mayo Full timeMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. With a 73,000-person workforce, Mayo Clinic cares for more than 1.3 million people each year with serious or complex illnesses from all 50 U.S. states and 130 countries. Mayo Clinic is the largest not-for-profit, multidisciplinary academic...
-
Lead Scientist, Neurobiology Research
1 week ago
Rochester, New York, United States Orro Full timeCompany Overview: Orro is a pioneering biopharmaceutical organization dedicated to the advancement of innovative genetic therapies aimed at addressing both rare and widespread medical conditions through its unique RNA editing technology. Orro is developing a diverse array of specialized programs that leverage the body's inherent RNA editing capabilities to...
-
Speech Language Pathologist
5 days ago
Rochester, New York, United States Soliant Full timeJob Opportunity for a Speech Language PathologistWe are seeking a skilled Speech Language Pathologist to join our team at Soliant Health. As a Speech Language Pathologist, you will be responsible for providing individualized education plans, conducting 1:1 therapy sessions, and writing goals for students with communication disorders.Responsibilities:Develop...
-
Senior Scientist, Disease Area Biology
10 hours ago
Rochester, New York, United States Orro Full timeAbout Korro BioKorro Bio is a biopharmaceutical company dedicated to developing innovative genetic medicines for rare and prevalent diseases using its proprietary RNA editing platform.We are committed to harnessing the body's natural RNA editing process to deliver precise and transient single base edits, expanding the reach of genetic medicines and improving...
-
Geriatric Psychiatry Specialist
1 week ago
Rochester, New York, United States University of Rochester Full timeInstitution: University of Rochester Medical CenterPosition Overview:The University of Rochester's Department of Psychiatry is seeking applications for a board certified psychiatrist dedicated to advancing their career within a dynamic academic medical institution. We are particularly interested in candidates for our Geriatric Outpatient clinics, focusing on...
-
Rochester, New York, United States Rochester Regional Health System Full timeOverview:As a Psychiatrist at Rochester Regional Health, you will play a pivotal role in transforming mental health care across central and western New York, enhancing the well-being of our patients. This is an opportunity to establish your professional aspirations, guide fellow clinicians, and contribute to meaningful healthcare initiatives.About Rochester...
-
Full Time General Surgery
3 months ago
Rochester, New York, United States Mayo Clinic Health System Full timeMayo Clinic in Rochester, MN is conducting a search for full time surgeons interested in either a 100% breast surgery practice or a combined breast and melanoma surgical oncology practice. We have a busy and growing practice across both disciplines. Our breast surgery practice is supported by a multidisciplinary team that encompasses all aspects of treatment...
-
Research Scientist
3 days ago
Rochester, New York, United States Mayo Clinic Full timeJob Summary:The Mayo Clinic is seeking a highly skilled Research Fellow to join our team in the Division of Nephrology and Hypertension. As a Research Fellow, you will be responsible for developing and implementing novel MRI technologies in our Center for Advanced Imaging Research.Key Responsibilities:Continuing and refining ongoing research projects in MRI...
-
Attending Physician in Psychiatry
3 days ago
Rochester, New York, United States University of Rochester Full timeUniversity of Rochester: Office of the Provost: University of Rochester Medical Center: School of Medicine and Dentistry: PsychiatrySalary Range or Pay Grade$220,400 - $368,692 a yearPosition OverviewThe University of Rochester's Department of Psychiatry is actively seeking a dedicated physician to become part of our dynamic primary care and hospitalist team...
-
Attending Physician in Psychiatry
1 week ago
Rochester, New York, United States University of Rochester Full timeUniversity of Rochester: Office of the Provost: University of Rochester Medical Center: School of Medicine and Dentistry: PsychiatrySalary Range or Pay Grade$220,400 - $368,692 a yearPosition OverviewThe University of Rochester's Department of Psychiatry is in search of a dedicated physician to enhance our dynamic primary care and hospitalist team within the...
-
Middle School Special Needs Educator
3 days ago
Rochester, New York, United States Talent Vision Full timeTalent Vision, a Staffing and Consulting Firm, is collaborating with a distinguished charter school to fill the role of Middle School Special Needs Educator. In this pivotal position, you will be instrumental in assisting students with varying educational requirements, ensuring they receive a high-quality learning experience. Your dedication to inclusivity...
-
Rochester, New York, United States University of Rochester Full timeInstitution: University of Rochester Medical CenterSalary Range: $415,000 - $455,000Position Overview:The Department of Imaging Sciences at the University of Rochester is in search of an ABR certified or eligible radiologist specializing in cardiothoracic imaging for a full-time faculty role. Candidates should possess fellowship training in cardiothoracic...