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Lead Scientist, Neurobiology Research
2 months ago
Company Overview:
Orro is a pioneering biopharmaceutical organization dedicated to the advancement of innovative genetic therapies aimed at addressing both rare and widespread medical conditions through its unique RNA editing technology.
Orro is developing a diverse array of specialized programs that leverage the body's inherent RNA editing capabilities to achieve precise and temporary modifications at the single base level.
By focusing on RNA rather than DNA, Orro is broadening the scope of genetic therapies, providing enhanced precision and flexibility, which may lead to greater specificity and improved long-term safety profiles.
Utilizing an oligonucleotide-based strategy, Orro aims to deliver its therapies to patients by capitalizing on its proprietary platform, established delivery methods, manufacturing expertise, and recognized regulatory pathways of approved oligonucleotide treatments.
Orro's flagship initiative targets Alpha-1 Antitrypsin Deficiency (AATD). We are committed to fostering a collaborative environment united by a shared mission.
We are cultivating a workforce of exceptional individuals with a bold vision to create transformative genetic therapies for prevalent health issues.
Our core values - Innovate for Tomorrow, Embrace Innovation, Collaborate Effectively, Distinctively Different, Compassion and Integrity - are integral to our culture.
These values are reinforced daily and serve as essential criteria in our recruitment process to ensure that Orro attracts top-tier talent and remains an excellent workplace.
Join us as we redefine the possibilities in genetic therapy and strive to make a meaningful difference in human health.
POSITION SUMMARY:
Orro is seeking a Senior / Principal Scientist in the Neurobiology division to lead and contribute to drug discovery initiatives targeting brain and spinal cord disorders.
The ideal candidate for this laboratory-focused role is a driven, collaborative, and innovative scientist who will design and execute experiments using human cell lines to propel discovery programs toward Investigational New Drug (IND) applications.
The successful applicant will exhibit clear and professional communication skills, collaborate effectively with colleagues in a complex organizational structure, and be adept at presenting scientific findings to project teams.
KEY RESPONSIBILITIES:
Develop, conduct, and analyze RNA editing experiments in neuronal cell lines, including human induced pluripotent stem cells (hIPSC), while collaborating with pharmacology teams on in vivo models of central nervous system (CNS) diseases.
Perform laboratory experiments to assess target engagement, elucidate mechanisms of action, evaluate therapeutic efficacy, and measure functional recovery in CNS models.
Coordinate and oversee studies conducted remotely at contract research organizations (CROs) and with external partners.
Conduct literature reviews to support ongoing projects and identify new indications for exploration within the emerging CNS pipeline.
Maintain detailed lab notebooks documenting data generated during assay development, in vitro, and in vivo studies.
Mentor and guide junior team members on laboratory best practices.
QUALIFICATIONS:
Ph.D. in Neuroscience, Molecular Biology, or Pharmacology with a minimum of 3 years of industry experience, or a Master's degree with at least 10 years of relevant experience.
Prior experience in designing and executing in vitro and in vivo studies related to neurodegenerative disorders such as ALS, FTD, PD, HD, AD, SCA, and targets including TDP43 and other proteinopathies is preferred.
Familiarity with a range of molecular biology techniques, including transcriptome analysis, RT-PCR, and in situ hybridization; experience in electrophysiology is advantageous.
Experience in oligonucleotide therapeutics or gene editing is a plus.
Strong attention to detail with excellent organizational and documentation skills.
Ability to collaborate across departments and understand applicable regulations concerning animal care and handling.
Highly motivated with the flexibility to adapt to changing priorities.
Exceptional written and verbal communication skills, capable of effectively interacting with peers and management, and presenting scientific data to multidisciplinary teams and key stakeholders.
Proficiency in software tools such as GraphPad Prism, electronic lab notebooks, and Microsoft Office for data analysis and figure preparation is essential.
COMPENSATION AND BENEFITS:
Orro provides competitive remuneration, including equity-based incentives, along with a comprehensive benefits package encompassing medical, dental, vision, a 401(k) retirement plan, life insurance, a dependent care flexible spending account, and a company-funded health savings account.
