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Postdoctoral Research Fellow – Chemical and Structural Biology

Dana-Farber Cancer Institute

Boston, MA

Full Time

Chemical and Structural Biology Postdoctoral Fellowship Position in the Walensky Laboratory, Dana-Farber Cancer Institute

The Walensky laboratory focuses on the chemical biology of deregulated protein interactions in cancer, metabolism, and infectious diseases. Our goal is to dissect and target pathologic protein interactions using multidisciplinary approaches that include (1) chemical and stapled peptide design, (2) rigorous biochemical, proteomic, and structural characterizations, (3) mechanistic validation in cells and mouse models, and ultimately (4) clinical translation. We emphasize mechanistic biology, including (1) canonical and non-canonical roles of BCL-2 family apoptotic proteins, (2) the p53 and RAS pathways, (3) high priority metabolic, bacterial and viral targets, and (4) novel helix-in-groove interactions relevant to protein structure, function, and drug development.

We seek a PhD candidate/graduate who is pursuing their first postdoctoral position and has deep experience in structural biology approaches to discern protein interaction mechanisms and blueprints for drug discovery and optimization.

See the Walensky group's most recent publications for a sampling of the lab's research projects and their multidisciplinary approach to scientific investigation:

Dr. Walensky is a chemical biologist and pediatric oncologist committed to advancing our understanding of fundamental cancer mechanisms and opportunities to target them with novel therapeutic strategies. Learn more at the Walensky lab's website:

Responsibilities

We are currently seeking a highly accomplished PhD candidate/graduate applying for their first postdoctoral fellowship in chemical and structural biology, with a focus on cancer. We are particularly interested in candidates who have solved structures using a spectrum of methods and applied the insights to dissect mechanisms of action.

Qualifications

PhD in Chemical Biology, Biochemistry, Structural Biology, Biophysics, or a related field is required. Publication track record, including first-authored publications, is preferred.

For more information and to apply, please visit:

About Dana-Farber Cancer Institute:

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.