Postdoctoral Fellow

1 month ago


Boston, Massachusetts, United States cweitz@hms.harvard Full time
Postdoctoral position in cryo-EM structural biology at Harvard Medical School


We are seeking an outstanding, highly-motivated postdoctoral fellow to join our team in the cryo-EM structural analysis of the endogenous multi-protein machines comprising the mammalian circadian clock, a molecular oscillator present in all or nearly all cells that drives daily rhythms of gene expression, physiology, and behavior.

Applicants should have a Ph.
D. degree and expertise in biochemistry and structural biology, including experience in cryo-EM structure determination. Our initial studies (e.g., Aryal et al., Mol. Cell, 2017) provided the first basic structural view of native circadian clock machinery from a eukaryote.

We have made progress in single-particle cryo-EM analysis of native circadian clock complexes purified from mouse tissues, and we aim to obtain high-resolution structures.

A successful outcome would have a revolutionary impact on our understanding of biological timekeeping and help create a new field of research in circadian biology.


Interested candidates should contact Chuck Weitz at Please include a cover letter, Curriculum Vitae, a brief statement of research expertise and interests, and contact information for three references.


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