Postdoctoral Research Fellow – Hill Lab
2 months ago
Postdoctoral Research Fellow – Hill Lab
Dana-Farber Cancer Institute
Boston, MA
Full Time
A Post-Doctoral Research Fellow position is available to join the Hill Laboratory in the Department of Medical Oncology at Dana-Farber Cancer Institute. We are looking for an enthusiastic scientist interested in hypothesis driven mechanistic research to work on our existing and upcoming projects.
Our group studies the role of the BRCA1 tumor suppressor along with other DNA damage repair and cell cycle regulatory proteins in regulation of DNA replication and cell cycle checkpoints in ovarian, endometrial, and breast cancers. We utilize immunofluorescence microscopy, cell and molecular biology, DNA damage repair, flow cytometry, and various sequencing assays on cell lines and patient-derived organoids to study DNA replication and cell cycle dynamics in different disease or pre-cancerous settings. We are particularly interested in how BRCA1 regulates replication origins. We hope to use our basic science findings to define better methods of prevention, early detection, and treatment of these difficult to treat women's cancers.
Requirements
Technical proficiency, scientific creativity, collaboration with others and independent thought. Works on problems of moderate to large scope in which analysis of situation or data requires a review of identifiable factors. Exercises judgment within defined procedures and practices to determine appropriate action. Design, conduct, and troubleshoot hypothesis-testing experiments. Design, conduct, and validate high-throughput, hypothesis-generating screens. Train and oversee the lab work of research technicians in the group. Maintain detailed and understandable lab notebooks. Interpret and discuss research findings with lab members and the principal investigator. Develop figures to depict research findings, write research and review papers, and present at scientific meetings.
Qualifications
Accomplished and motivated candidates will have a PhD in biomedical sciences and those with significant experience in molecular biology and cell biology are encouraged to apply. Technical skills in basic techniques like western blotting, co-immunoprecipitation, fluorescence microscopy, cell cycle flow cytometry profiling, and standard DNA damage repair assays in human cell lines are important. Clear thinking, writing, and communication skills are absolutely needed. A record of scientific accomplishment as shown by a peer-reviewed original research paper(s) is required. Motivation to obtain fellowships to support your work at Dana-Farber and Harvard is critical.
For more information and to apply, please visit:
About Dana-Farber Cancer Institute
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.
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