Head of Platform Biology

3 weeks ago

Cambridge, United States Life Science People Full time

Drive Innovation in Drug Discovery through AI

We have partnered with a groundbreaking client at the forefront of artificial intelligence and biotechnology. They are leveraging their proprietary AI platform to decode RNA biology and develop transformative therapies.


About the Role

Position: Head of Platform Biology

Reports to: Chief Scientific Officer

Location: Massachusetts, USA


As the Head of Platform Biology, you will lead the application of a cutting-edge AI platform to prioritize drug targets and design highly optimized lead molecules across therapeutic modalities such as ASOs, siRNA, mRNAs, and gene editors. You will build and mentor a high-performing team, define and execute strategic initiatives, and contribute to the development of groundbreaking genetic medicines.


Key Responsibilities

  • Collaborate with stakeholders to define and grow strategies that expand the AI platform’s impact on genetic medicines.
  • Develop a biology-driven screening platform to support AI-driven drug discovery.
  • Lead target selection, hit identification, and validation campaigns using functional genomics, disease models, and the AI platform.
  • Deliver proof-of-concept data for optimized molecules showcasing the AI platform’s capabilities.
  • Validate and cross-verify platform-discovered targets through experimental approaches including functional genomics, mechanistic biology, and disease models.
  • Contribute to strategic initiatives for advancing findings into clinical development through partnerships and business development activities.
  • Build a culture of scientific rigor and high-quality proprietary data generation.
  • Act as the subject matter expert for cell biology and therapeutics development, collaborating closely with ML, Target ID, and Genomics teams.
  • Present results at internal and external venues and publish in peer-reviewed journals as appropriate.


Basic Qualifications

  • PhD in biological sciences with 15+ years of experience in early-stage drug development focused on target validation and nucleic acid therapies.
  • 8+ years of experience building and leading teams to achieve organizational goals.
  • Broad therapeutic expertise and familiarity with modalities such as gene editing and RNA-targeted therapies.
  • Strong knowledge of target discovery through human genetics and experimental validation of novel target hypotheses.
  • Proven ability to work cross-functionally in fast-paced, technical environments.
  • Strong leadership qualities, including a strategic mindset, organizational skills, emotional intelligence, and creativity.
  • Experience communicating complex data clearly to stakeholders from diverse backgrounds.
  • Prior experience managing collaborations with biotechnology, academic, and CRO partners.


Preferred Qualifications

  • Expertise with genetically defined targets in the liver and CNS, including corresponding models and delivery systems.
  • Hands-on experience developing and running industrialized NGS-based workflows.
  • Computational background or ability to collaborate with computational biology teams on scalable analytics.
  • Experience managing multi-site projects and leading distributed teams.


What’s on Offer

  • Competitive salary and equity ownership opportunities.
  • Comprehensive benefits and growth opportunities.
  • The chance to work at the intersection of AI and biotechnology, contributing to transformational advancements in medicine.


This role offers the chance to be at the forefront of innovation in genetic medicine. If you're passionate about leveraging AI and biology to drive therapeutic breakthroughs, we encourage you to apply. Only candidates selected for interviews will be contacted.

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