![Inograft Biotherapeutics](https://media.trabajo.org/img/noimg.jpg)
Senior Director of Protein Engineering
2 months ago
ABOUT INOGRAFT BIOTHERAPEUTICS
Inograft is a preclinical-stage biotechnology company focused on the development of best-in-class non-genotoxic bone marrow conditioning regimens for bone marrow transplantation. Formed in late 2022, with founders from Stanford University School of Medicine and Forty Seven Inc. (acquired by Gilead in 2020 for $4.9B), Inograft aims to develop life-changing therapies by applying proven stem cell therapies to areas of significant unmet medical need, including genetic disorders, autoimmune diseases, aging, and organ transplant.
JOB DESCRIPTION
Inograft is seeking a highly intellectual, confident, and collaborative manager with a strategic mindset to lead our protein engineering division. This position’s responsibilities will span the development of our current lead assets into clinical stages of development, as well as working to generate and select additional assets from the discovery stage. As the team leader, this position will require management and mentorship of a team with a diversity of backgrounds and experiences spanning from research associates to senior scientists. This role will require the incorporation of continually evolving data from our passionate multidisciplinary teams, including basic scientists, translational scientists, and clinicians into non-human primate proof-of concept studies and thereafter into IND-enabling studies.
KEY RESPONSIBILITIES
- Oversee the design, development, and optimization of novel proteins, including antibodies and fusion proteins
- Oversee the design and validation of the assays for the selection of these antibodies and fusions proteins, including for IND filing
- Select and manage external CROs involved in protein production, affinity maturation, and CMC optimization
- Manage multiple projects simultaneously as there will be various targets/assets being considered in parallel at different stages of development
- Coordinate and represent protein engineering at cross-functional meetings within R&D as well as with company leadership
- Provide data summaries and strategic advice to Inograft Leadership and Board of Directors
QUALIFICATIONS AND EXPERIENCE
- PhD degree in biochemistry, structural biology, or a related field
- Minimum 10 years of experience in protein engineering, including at least 4 years in a leadership role in biotech
- Experience in leading biologics discovery programs
- Extensive experience in antibody structure, function, and engineering techniques
- Familiarity with leading protein engineering techniques, including yeast display and phage display
- Familiarity with regulatory and CMC requirements for therapeutic protein development
- Excellent leadership, mentorship, project management, and communication skills with ability to inspire peers and junior members to drive towards a common goal
- Comfort with working in a fast-paced biotech environment
- Strong publication/patent record
The anticipated salary range for this position is $240,000 to $275,000. The actual salary will be dependent on various factors that may include experience level, knowledge, skills and abilities.
Inograft Bio offers a competitive salary and benefits package.
Please submit resumes to careers@inograft.com.
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