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Associate/ Senior Associate Scientist in Protein Engineering
3 months ago
General Summary
We are seeking a skilled scientist with a background in Protein/Enzyme engineering and molecular biology in the Bioengineering Department at BioMap. This position will mainly focus on computation-aided library generation, high-throughput screening, recombinant protein/enzyme production, and molecular biology.
We are a multi-disciplinary team working closely with computational scientists on nanobodies, antibodies, and enzymes, supporting the discovery of bio-therapeutics through our engineering expertise. The successful candidate has a background within protein engineering and molecular biology, and preferably experience with HT display methodologies in the library generation, and automation platform development.
This is a great opportunity to work with world-class biologists, AI/ML scientists, and engineers to explore next-generation therapeutical drug development.
Keywords: Protein/Enzyme production, Molecular biology
Job Responsibilities
- Working closely with other scientists on protein/enzyme engineering projects by using yeast display, NGS, flow cytometry, liquid handler, microplate reading.
- Help design the DNA constructs, and generate the synthetic DNA library by molecular biology techniques, including RT-PCR, gene cloning, yeast transformation, mammalian cell transfection, etc.
- Analyze libraries by FACS sorting and NGS to screen for lead candidate.
- Help develop the high-throughput flow cytometry and plate-reader analysis platform.
- Assist the HTP protein/enzyme characterization and assay development.
- Collaborate with cross-functional teams for project development.
- Routine laboratory instruments maintenance, including flow cytometry, PerkinElmer Liquid Handling system.
- Demonstrate ability to combine, analyze, and visualize data from multiple sources.
- Attend internal and external meeting to represent the department or company for project presentation.
Qualifications
- A Bachelor's in Biochemistry with 3+ years of relevant experience is required. A Master's or a Ph.D degree in subject matter expertise is preferred.
- Relevant required experience includes some combination of the following skills:
- Recombinant protein and enzyme production in mammalian cells, experience in protein purification systems (such as AKTA).
- Experience with synthetic DNA library amplification, and DNA construct generation.
- Good understanding of antibody and enzyme science.
- Experience with different protein formats, such as antibody, nanobody, mini-binder, and enzyme is a plus.
- Experience with Display technologies, Flow cytometry, NGS is a plus.
- Experience with PerkinElmer Liquid Handling system is a plus.
- Experience with protein characterization (SPR/BLI, functional validation) is a plus.
- Familiar with industrial working standards, including LIMS is a plus.
- Demonstrates excellent verbal and written communication skills.
- Good working attitude in a fast-growing organization.
BioMap is an equal opportunity employer and values diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
