Senior Process Development Associate

4 weeks ago


South San Francisco, United States Astrix Full time

This is a unique opportunity to work at the intersection of genomics and therapeutics and participate in the development of a diverse therapeutic pipeline driven by a transformative core technology.


The Senior Process Development Associate is responsible for execution of purification process development studies, and purification of samples supporting upstream PD. The ideal candidate will be hardworking, flexible, and able to work on multiple projects in a fast-paced and dynamic environment.




Location: South San Francisco, CA

Schedule: M-F: 9am-4pm


Responsibilities:

  • Develop and carry out bench scale unit operations for rAAV purification including chromatography, depth filtration, tangential flow-filtration, and viral filtration
  • Utilize analytical methods including ddPCR, ELISA, Refyn, Picogreen, Alkaline gel, CE-SDS, SEC[1]HPLC
  • Analyze, interpret, and present process performance and product quality data
  • Meticulously maintain complete and accurate records of all work performed in an ELN
  • Contribute to authoring and reviewing technical reports and SOPs
  • Participate in process transfer activities Docusign Envelope


Qualifications:

  • B.S. or M.S. in chemical engineering, biochemical engineering, biochemistry, or related field
  • 3-6 years of industry experience in purification process development or similar role
  • Skill with chromatography instrumentation and control software, especially Äkta systems and UNICORN software
  • Experience with running characterization and analytical assays
  • Proficient with Microsoft Office suite including Excel, Powerpoint, and Word


Preferred Qualifications:

  • Experience with AAV purification and quality parameters
  • Capability to perform statistical data analysis, which may include DoE, use of JMP software
  • Familiarity with Empower, SoftMax Pro, and other analytical assay software



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