Postdoctoral Fellow, Inflammation and Fibrosis
2 months ago
Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.
What You Will Achieve
The Myeloid and Tissue Remodeling group, as part of Inflammation and Immunology Research Unit, at Cambridge, MA is seeking a highly driven and innovative Ph.D.-level scientist to join our discovery group as postdoctoral research fellow in driving therapeutic innovation through exploration of fibrotic disease pathophysiology.
The Postdoctoral Fellow will embark on a research project aiming to define cellular and molecular mechanisms of chronic injury resolution. This is a unique opportunity to be trained at the interface of fibrogenesis and scar regression, work collaboratively with diverse research teams within Pfizer, and publish at high-impact journals.
The ideal candidate should have solid training in immunology and good understanding of RNA sequencing techniques. By the end of the program, the Postdoctoral Fellow will be proficient in inflammation and fibrosis biology, cutting-edge single-cell RNA sequencing-based cell profiling and implementing chronic fibrosis preclinical models.
How You Will Achieve It
Contribute intellectually and at the bench to the project conception, design and execution.
Independently interpret and analyze data and communicate findings to mentor.
Being proactive to solve problem, by identifying problems and proposing ways to resolve them before the impacts are felt.
Collaborate and develop close partnerships with Next-Generation Sequencing team members working on developing pipelines spanning cell preparation to sample analysis.
Present the research work at various internal and external meetings and publish in high-impact journals.
Ensure all tasks and responsibilities are carried out according to scientific and ethical standards.
Exercise and build basic team effectiveness skills {e.g., commitment, feedback, consensus management) within context of immediate work group.
Qualifications
Must-Have
Ph.D. in cell biology or immunology.
No more than 2 years of post-degree experience.
At least 1 first-author publication (published or manuscripts submitted for publication) in high-quality specialty or general readership journals
Experience in in vivo disease models, tissue harvesting, dissociation, and cell isolation.
In vitro culture of primary cells and cell lines.
Demonstrated experience in diverse molecular and biochemical laboratory techniques applied to cell characterization at molecular or genetic levels (immunofluorescence, flow cytometry, qPCR, RNA sequencing)
Well organized, self-motivated, team oriented, ability to multitask with attention to detail
Excellent communication and writing skills
Proficient in computational analysis and coding pipelines (R Studio, Python, etc.)
Willingness to make a minimum 2-year commitment.
Nice-to-Have
Possess experience using fibrotic disease relevant animal models
In-depth, hands-on knowledge of single-cell RNA sequencing
Experience with complex culture/co-culture systems of primary cells including endothelial, immune, and fibroblast culture.
PHYSICAL/MENTAL REQUIREMENTS
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.
OTHER JOB DETAILS
Must have work authorization in the US.
Work Location Assignment:Flexible. Flexible colleagues are assigned a Pfizer site within a commutable distance where they work about 2-3 days weekly to connect and innovate with their team face-to-face. However, they also benefit from being able to work offsite regularly when it makes sense to do so.
The annual base salary for this position ranges from $60,900.00 to $101,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
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