Postdoctoral Fellow, Energy Metabolism

3 weeks ago

Cambridge, United States Pfizer Full time

Why Patients Need You

At Pfizer we deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

This is an exciting opportunity to join the Internal Medicine Research Unit (IMRU). The key strategic focus area within the IMRU at Pfizer is identifying novel therapies to prevent or treat chronic diseases associated with diabetes or the metabolic syndrome including obesity, renal disease and heart failure. Our goal is to build a world class research team of dedicated scientists committed to developing a deep mechanistic understanding of the metabolic pathways underlying disease pathogenesis.

As a member of the metabolic biology team, we are seeking a Postdoctoral Fellow to interrogate novel mechanisms of energy metabolism in cardiometabolic diseases. The successful candidate must be able to independently drive their research project as well as collaborate effectively with a wide spectrum of scientific partners representing diverse disciplines. Knowledge and experience in the study of metabolic pathways is essential and familiarity with the pathophysiology of dysmetabolic states would be advantageous.She/he will have daily interactions with a team of creative and innovative scientists, working in a supportive environment to conduct rigorous scientific and drug discovery research. Strong self-motivation, excellent communication and interpersonal skills, and the ability to both lead as well as work as part of a team are essential.

How You Will Achieve It

Successful candidates will be expected to:

  • Plan and execute in vivo/ ex vivo/ in vitro laboratory experiments independently (includingexperimental design, data collection, analysis, interpretation, and presentation).

  • Develop relevant metabolic assays to understand changes in energy generation that occur in kidney disease.

  • Quantify and translate experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by disease and how they respond to therapeutic interventions.

  • Presentresearch findings toPfizer colleagues andthe scientific community through publications in peer-reviewed journals andtalks and postersat scientific meetings.

  • Ensure all tasks and responsibilities are carried out according to scientific and ethical standards.

Qualifications

Must-Have

  • PhD in Biology, Physiology, Biochemistry or a relevant field to the position.

  • Expertise in core molecular and biochemical laboratory techniques (qPCR, ELISA, WB/IP, plate-based assays, DNA/RNA isolation).

  • Expertise in energy metabolism and/or signaling pathways.

  • Experience with in vivo mouse models (e.g. handling, dosing, tissue collection)

  • Ability to conduct data analysis using Microsoft Excel, GraphPad Prism or equivalent software.

  • Demonstrated ability to review critically available data and to think creatively in formulating novel hypotheses.

  • Well organized, self-motivated, team oriented, ability to multitask with attention to detail.

  • Excellent communication and writing skills.

  • Successful record of scientific accomplishments as indicated by scientific publications and/or presentations.At least one first-author publication in peer-reviewed scientific journals.

  • Willingness to make a minimum 2-year commitment.

  • No more than 2 years of post-degree experience.

Nice-to-Have

  • Expertise with renal disease models and/or biology.

  • Experience in tissue digestion and staining for flow cytometry or cell sub-population separation techniques (i.e. magnetic bead-based).

  • Experience with radioactive or stable isotope-based metabolic flux analysis of energy substrates (i.e. oxidation, synthesis, uptake or A-V balance).

PHYSICAL/MENTAL REQUIREMENTS

  • In vivo vivarium work

OTHER JOB DETAILS

  • Must have work authorization in the US.

  • Work Location Assignment:On Premise. On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.

The annual base salary for this position ranges from $60,900.00 to $101,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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