Postdoctoral Fellow, Quantitative Systems Pharmacology
2 months ago
At Pfizer we deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.
What You Will Achieve
Quantitative Systems Pharmacology (QSP) is a discipline that uses mechanistic mathematical modeling and simulation to enhance the robustness and quality of decision-making from exploratory research through clinical development.
We are seeking a highly motivated Postdoctoral Research Fellow to develop QSP models to advance our understanding of preclinical to clinical translation of vaccines. By integrating information across complementary preclinical and clinical sources into a modeling framework, the Postdoctoral Fellow will evaluate specific mechanistic hypotheses and aim to generate novel insights to enable the quantitative prediction of clinical vaccine immunogenicity from preclinical data. The development of this quantitative framework for predicting clinical vaccine immunogenicity will potentially streamline candidate selection and de-risk development decisions via optimal trial design.
This is an exciting opportunity to work within an industry leading, cross-functional team who are at the forefront of the development and application of quantitative systems pharmacology models to address critical uncertainties in drug discovery and development.
The successful candidate will have earned a Ph.D. in Applied Mathematics, Engineering, Statistics, Physics, Pharmaceutical Sciences, or other related discipline and has a demonstrated track record in scientific publications.
How You Will Achieve It
The Postdoctoral Fellow will develop and utilize mathematical models toward enhanced quantitative understanding of immunogenicity mechanisms based on published and internal data.
This may include but is not limited to:
Employing modeling and simulation techniques for vaccine immunogenicity prediction.Identifying relevant data (in vitro and in vivo preclinical and clinical study data) for model development, optimization, and validation.Designing nonclinical experiments aimed towards generating data for model validation and testing of relevant hypotheses.Effectively communicating model results and outcomes to scientists in both quantitative and non-quantitative disciplines.Primary authorship on scientific publications and presenting at internal and external scientific meetings.
Qualifications
Must-Have
Ph.D. in Applied Mathematics, Mathematical Biology, Chemical Engineering, Biomedical Engineering, Statistics, Physics, Pharmaceutical Sciences or related discipline with strong numerical components focusing on mathematical modeling and simulation.Training or previous experience in building QSP or differential equation-based models of biological or physiological pathways/systems is required.At least one first-author publication in peer-reviewed scientific journals.No more than 2 years of post-degree experience.Willingness to make a minimum 2-year commitment.
Nice-to-Have
Understanding of theory, principles, and statistical aspects of mathematical modeling and simulation, including parameter estimation techniquesIn-depth understanding of ordinary differential equations (ODEs) and how these can be applied in the development of complex models of biological pathways and systemsIn-depth, hands-on knowledge of modeling and simulation software (MATLAB/Simbiology, Julia, Python, R, C/C++ preferred)Keen interest in learning new areas of biology and building on a solid foundation of quantitative and computational skillsSelf-directed with ability to work independentlyTeam player mindsetExcellent communication and writing skills
PHYSICAL/MENTAL REQUIREMENTS
Ability to perform mathematical calculations and ability to perform complex data analysis.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Office-based position with infrequent travel to scientific conferences and/or business meetings.
OTHER JOB DETAILS
Must have work authorization in the US.Work Location Assignment:Flexible. Flexible colleagues are assigned a Pfizer site within a commutable distance where they work about 2-3 days weekly to connect and innovate with their team face-to-face. However, they also benefit from being able to work offsite regularly when it makes sense to do so.
The annual base salary for this position ranges from $60,900.00 to $101,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
-
Cambridge, United States Harvard University-EPS Department Full timeJob Description: Professor Brendan Meade invites applications for a Postdoctoral Fellow position. We have an open position for a postdoctoral fellow with a background in geophysics, earthquake science, or other similarly quantitative fields. Research projects will be focused on imaging earthquake cycle kinematics, statistical earthquake cycle models,...
-
Senior Director, Quantitative Pharmacology
4 weeks ago
Cambridge, United States Flagship Ventures Full timeCompany Summary Founded by Flagship Pioneering in 2021, Metaphore aims to unlock breakthroughs that outperform today's drugs for maximum patient impact, We adapted this idea to drug discovery. MIMIC™, our computationally driven bioplatform that couples machine learning with molecular mimicry, engineers therapeutics to trigger a desired biological response....
-
Cambridge, Massachusetts, United States Harvard University Full timeDetailsTitlePostdoctoral Fellow in Computer Science: Machine Learning SystemsSchoolHarvard John A. Paulson School of Engineering and Applied SciencesDepartment/AreaComputer SciencePosition DescriptionProfessor Stratos Idreos solicits applications for a Postdoctoral Fellow position in Harvard Computer Science, starting on September 1st 2024. We are interested...
-
Postdoctoral Fellow
2 months ago
Cambridge, United States Harvard University Full timeDepartment/Area Position Description The Digital, Data, and Design Institute at Harvard is accepting applications for a Postdoctoral Fellow for academic year 2024-2025 to work on research activities with the Laboratory for Innovation Science at Harvard. D^3 launched in the summer of 2022 with 12 labs working on research at the intersection of academia...
-
Cambridge, Massachusetts, United States Union Chimique Belge Full timePosition OverviewAs a key contributor at Union Chimique Belge, the Senior Scientist in Quantitative Clinical Pharmacology will play a pivotal role in advancing our understanding of pharmacokinetics and pharmacodynamics across various therapeutic areas.Key ResponsibilitiesLead quantitative clinical pharmacology initiatives for designated projects.Collaborate...
-
Cambridge, Massachusetts, United States MIT Full timePosition Overview:Postdoctoral AssociateCompany: MITAre you driven by the challenge of exploring the economic and ecological dimensions of materials systems? We are seeking a Postdoctoral Associate to engage in research focused on the extraction, processing, and recovery of minerals essential for the energy transition.Dynamic modeling of materials...
-
Cambridge, Massachusetts, United States UCB Full timeImpact Patients Through Science POSITION OVERVIEW As a key member of our team, the Lead Scientist - Quantitative Clinical Pharmacology / PK-PD Specialist will concentrate on quantitative clinical pharmacology initiatives across various diseases and therapeutic domains. This role is pivotal in advancing both Early and Late Clinical Development at UCB,...
-
Cambridge, Massachusetts, United States UCB Full timeMake your mark for patients POSITION DESCRIPTIONOur new Principal Scientist – Quantitative Clinical Pharmacology / PK-PD Lead will focus on quantitative clinical pharmacology activities in selected diseases/therapeutic areas and assigned project(s) to drive further Early and Late Clinical Development within UCB, working with other functional experts to...
-
Cambridge, Massachusetts, United States UCB Full timeMake your mark for patients POSITION DESCRIPTIONOur new Principal Scientist – Quantitative Clinical Pharmacology / PK-PD Lead will focus on quantitative clinical pharmacology activities in selected diseases/therapeutic areas and assigned project(s) to drive further Early and Late Clinical Development within UCB, working with other functional experts to...
-
Physics, Postdoctoral Fellow
2 months ago
Cambridge, Massachusetts, United States Harvard University Full timeHarvard UniversityTitle: Harvard University, Physics, Postdoctoral FellowSchool: Faculty of Arts and SciencesDepartment_Area: PhysicsPosition Description: The Yelin group at Harvard University expects to appoint a postdoctoral fellows in January 2025. We are looking for candidates with interests in the work on cooperative ordered atomic system in various...
-
Cambridge, Massachusetts, United States Harvard University Full timeHarvard UniversityTitle: Postdoctoral Fellow in Artificial Intelligence for SocietySchool: Harvard John A. Paulson School of Engineering and Applied SciencesDepartment_Area: Computer SciencePosition Description: The Teamcore Group ) at the John A. Paulson School of Engineering and Applied Sciences ( SEAS ) at Harvard University seeks motivated postdoctoral...
-
Postdoctoral Fellow
4 weeks ago
Cambridge, Massachusetts, United States Amgen Full timeHOW MIGHT YOU DEFY IMAGINATION?Youve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology...
-
Postdoctoral Research Fellow
2 months ago
Cambridge, Massachusetts, United States Harvard University Full timeHarvard UniversityTitle: Postdoctoral Research FellowSchool: Harvard School of Dental MedicineDepartment_Area: Silva Lab/Department of Oral Medicine, Infection, and ImmunityPosition Description: The Silva Lab for Hemostasis and Immunity Research at the Harvard School of Dental Medicine is recruiting one immunology postdoctoral researcher. The postdoc is...
-
Cambridge, United States UCB Full time Make your mark for patients  POSITION DESCRIPTIONOur new Principal Scientist â Quantitative Clinical Pharmacology / PK-PD Lead will focus on quantitative clinical pharmacology activities in selected diseases/therapeutic areas and assigned project(s) to drive further Early and Late Clinical Development within UCB, working with other functional...
-
Postdoctoral Associate, Materials Systems Lab
5 months ago
Cambridge, United States MIT Full timeJob Description POSTDOCTORAL ASSOCIATE , Materials Research Laboratory (MRL)-, to conduct research on the economic and environmental aspects of materials systems. Will work on the extraction, processing, and recovery of minerals related to the energy transition. The research will focus on several of the following topics: dynamic modeling of materials...
-
Cambridge, United States UCB Full time Make your mark for patients  POSITION DESCRIPTIONOur new Principal Scientist â Quantitative Clinical Pharmacology / PK-PD Lead will focus on quantitative clinical pharmacology activities in selected diseases/therapeutic areas and assigned project(s) to drive further Early and Late Clinical Development within UCB, working with other functional...
-
Postdoctoral Fellow in Evolutionary Neuroscience
2 months ago
Cambridge, Massachusetts, United States Harvard University Full timeHarvard UniversityTitle: Postdoctoral Fellow in Evolutionary NeuroscienceSchool: Faculty of Arts and SciencesDepartment_Area: Human Evolutionary BiologyPosition Description: The Department of Human Evolutionary Biology at Harvard University invites applications for a Postdoctoral Fellow in the Evolutionary Neuroscience Laboratory of Dr. Erin Hecht to...
-
Postdoctoral Fellow, Inflammation and Fibrosis
2 months ago
Cambridge, United States Pfizer Full timeWhy Patients Need YouPfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or...
-
Research Scientist in Materials Systems
5 days ago
Cambridge, Massachusetts, United States MIT Full timePosition Overview:Postdoctoral ResearcherCompany: MIT Materials Research LaboratoryAre you dedicated to exploring the economic and ecological dimensions of materials systems? We are seeking a Postdoctoral Researcher to focus on the extraction, processing, and recovery of minerals pertinent to the energy transition.Dynamic modeling of materials...
-
Postdoctoral Researcher
3 months ago
Cambridge, Massachusetts, United States Brigham and Women's Hospital, Harvard Medical School - Center for Engineered Therapeutics Full timePostdoctoral researcher with a background in 3D printing and/or additive manufacturing of biomaterials and medical devices. We are seeking a highly motivated and talented postdoctoral researcher who is highly committed to developing successful research careers with a background in 3D printing and/or additive manufacturing of biomaterials and medical...
