Scientist, ADC Discovery Research
2 weeks ago
Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
You will participate in pre-clinical drug discovery and development projects with a focus on antibody-drug conjugates (ADC) that target oncogenic pathways and processes. You will work as a member of the ADC Biology team, performing a range of in vitro pharmacology and pharmacodynamic assays to understand the structure-activity relationships (SAR) of novel ADC payloads. You will be a technical and scientific specialist in the conduct of SAR studies and will be responsible for experimental study planning, design, and execution. You will be responsible for data collection, appropriate documentation, and accurate reporting and presentation of study data for multidisciplinary teams. You will work collaboratively in matrixed and cross-functional teams to efficiently address project needs in a timely manner.
Key Responsibilities
Apply cellular and molecular biology laboratory techniques to preclinical research projects in the area of cancer biology, with a focus on oncogenic tumor dependencySupport drug linker discovery and PD marker activities through execution of molecular and cell-based methodologies, including cytotoxicity assays, reporter assays, AlphaLISA/ELISA, and WES.Investigate novel biological MOAs of ADC linker payloads through development, optimization, and execution of complex assaysIndependently design, execute and document key experiments to enable clear go/no-go decisions; present findings to large and small audiencesProvide leadership within technical area of expertise; may train othersMaintain rigorous records of experimental progress using electronic laboratory notebooks
Qualifications
Must-Have
Bachelor's Degree and 6+ years of experience or Master's degree and 4+ years of experienceDegree in Molecular and Cellular Biology, Biochemistry, or a related fieldExperience with tissue culture and diverse molecular biology techniques,Ability to adapt and adjust to a rapidly evolving environmentAbility to use critical thinking to address challenges and overcome obstaclesStrong written and verbal communication skills with the ability to communicate effectively to a wide range of audiences
Nice-to-Have
Experience working in the industry environmentBackground in cancer drug discovery related to ADC biologyExperience in protein degradation and proteostasis is strongly preferred
The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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