Principal Scientist

7 days ago

Bothell, United States Pfizer, S.A. de C.V Full time

We're in relentless pursuit of breakthroughs that change patients' lives. We innovate every day to make the world a healthier place.

To fully realize Pfizer's purpose – Breakthroughs that change patients' lives – we have established a clear set of expectations regarding "what" we need to achieve for patients and "how" we will go about achieving those goals.

This position is based at our Bothell, WA site which is approximately 15 miles from the downtown Seattle area. POSITION SUMMARY

You will participate in pre–clinical drug discovery and development projects with a focus on ADC Biology and Cancer Immunology. You will be responsible for working with project teams to design, plan and execute an in vivo strategy to ensure efficient and effective decision–making. You will also be a key stakeholder/ contributor to the In Vivo Committee, responsible for vetting study designs and strategies and ensuring timely completion of research project objectives. You will directly supervise laboratory staff that make up an in vivo team responsible for study execution and data analysis, in addition to playing a role in the In Vivo Pharmacology department strategy. You will provide technical and scientific expertise in in vivo pharmacology across the Oncology Research Unit (ORU) to enable target identification, validation, prioritization and efficient drug discovery. POSITION RESPONSIBILITIES

Collaborate across project teams to establish in vivo strategy and study plans for drug discovery projects.Serve as the in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical in vivo data to enable project stage dependent decisions.Work within multi–functional teams to support target identification, validation, drug discovery and combination therapy.Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology.Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.Supervise and guide a small team of scientists.Develop and characterize new in vivo mouse models, including cell–line derived xenografts, syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.Ensure team members comply with all regulatory requirements and internal policies.Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team, if necessary.Interpret, present and document experiments as well as prepare reports. Written and verbal presentation of results within a multidisciplinary team environment.Contribute to relevant in vivo sections of study reports and regulatory documents e.g., IND filings.Publication of results in scientific peer–reviewed journals and presentations at internal, national, and international meetings. QUALIFICATIONS

Must–Have

Ph.D. in Cancer Biology, Immunology, Genetics or a related discipline.Minimum 5 years industry experience including technical and scientific experience in drug discovery and preclinical development.Experience in collaborative research in Oncology drug discovery programs.Experience with animal models of human cancers.Hands–on in vivo (e.g., IV, PO dosing, blood/tissue collection) and ex vivo skills (e.g., flow cytometry, western blot, ELISA).Experience supervising a small team of Scientists.Excellent written and oral communication and presentation skills.Proficiency with all common office and scientific software.

Preferred

Strong track record of publications or evidence of equivalent achievements in industry.Experience with GEMM and humanized models.Experience with Antibody Drug Conjugates (ADC). PHYSICAL/MENTAL REQUIREMENTS

Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis. NON–STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Must be willing to work after hours as needed to ensure study integrity. Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Benefits at Pfizer

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.

Our Competitive Benefits Programs help our colleagues by:

Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing.Strengthening Colleagues' Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves.And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on–site health and/or fitness centers, movement and mindfulness solutions, "Log in for your Day" work flexibility and so much more.

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