Senior Scientist, Biochemical Assay Development

4 weeks ago

Boston, United States Eurofins Lancaster Laboratories Professional Scientific Services, LLC Full time
Sr. Scientist, Biochemical Assay Development

Employee Responsibilities:

This position will involve performing biochemical assay development for HTS/MTS campaigns; to support med chemistry effort and test potency of research compounds (SAR, MOA, etc.)

The Ideal Candidate would possess:

  • Experience successfully carrying out basic lab operation (buffer preparation/characterization; solutions, sample preparation, dilution, basic instrument troubleshooting and problem solving so to minimize equipment downtime).
  • Biochemical assay development and execution : Develop high quality, robust biochemical assays for MTS/HTS campaigns; the potency and MOA testing of small molecules to support drug discovery
    • Determine kinetic characteristics of an enzyme activity including Km, linearity, stability, tolerability, etc.
    • Complete the development successfully
      • Achieve a robust enzyme response with compliance to NIH guidelines
      • Perform HML and IC50 tests
    • Timely record critical experimental findings and communicate back to the team and med chemistry group
    • Achieve turnaround time for compound testing within 24-48 hours
    • Make sound judgment on scientific merits and seek advice when appropriate
  • LC/MS methods: Carry out biochemical assays using LC/MS technology
    • Develop successful LC/MS method for detection of analyte of interest (collaboration with Analytical R&D, Waltham)
    • Prepare calibration curves
    • Achieve desired assay window
      • Minimize background and carryover signals
    • Timely record all experimental findings in adequate details in eLN
    • Seek advice when appropriate
Minimum Qualifications:
  • B.S. with 4-6 years of related experience or M.S. with 2-3 years of related experience
  • Authorization to work in the United States indefinitely without restriction or sponsorship
What we offer:
  • Excellent full time benefits including comprehensive medical coverage, dental, and vision options
  • Life and disability insurance
  • 401(k) with company match
  • Paid vacation and holidays
Candidates currently living within a commutable distance of site are encouraged to apply.

Eurofins Lancaster Laboratories Professional Scientific Services ® (PSS) is a global, award-winning insourcing solution that places our people at our clients' site dedicated to running and managing laboratory services while eliminating headcount, co-employment and project-management worries.

We infuse our 55-year track record of scientific and laboratory operations expertise, as well as HR and great place to work best practices, to recruit, hire, train and manage highly qualified scientists to perform laboratory services using our client's quality systems and equipment.

Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.

  • Scientist II/Senior Scientist, Biochemistry

    3 months ago

    Boston, United States NextRNA Therapeutics Full time

    As a Scientist II / Senior Scientist, Biochemistry at NextRNA Therapeutics, you will join an interdisciplinary team of highly creative and talented individuals whose vision is to improve patients’ lives by expanding the space of RNA-targeted Therapies. You will be a key team member responsible for integrating biochemical technologies with our drug...

  • Senior Scientist, Discovery

    3 months ago

    Boston, United States PepGen Full time

    Job DescriptionJob DescriptionPosition SummaryWe are seeking an Senior Scientist, Discovery who will report to our Senior Director, Discovery Biology. They will be responsible for executing biochemical and cellular assays to support drug discovery efforts. The ideal candidate will be experienced with the testing of chemical compounds, data analysis and...

  • Biochemistry Scientist II/Senior Researcher

    2 weeks ago

    Boston, Massachusetts, United States NextRNA Therapeutics Full time

    As a Biochemistry Scientist II / Senior Researcher at NextRNA Therapeutics, you will be part of a dynamic and innovative team dedicated to enhancing patient outcomes through advanced RNA-targeted therapies. Your role will be pivotal in merging biochemical methodologies with our drug development initiatives. About You:You possess a wealth of experience in...

  • Scientist II/Senior Scientist, Biochemistry TR-FRET

    3 months ago

    Boston, United States NextRNA Therapeutics Full time

    As a Scientist II / Senior Scientist, Biochemistry at NextRNA Therapeutics, you will join an interdisciplinary team of highly creative and talented individuals whose vision is to improve patients’ lives by expanding the space of RNA-targeted Therapies. You will be a key team member responsible for integrating biochemical technologies with our drug...

  • Senior Research Scientist BioScience

    7 days ago

    Boston, United States AstraZeneca GmbH Full time

    Are you passionate about shaping the future of drug discovery?Senior Research Scientist BioScience (PhD + Postdoc experience)Oss, The NetherlandsFulltimeIn our BioScience team at Acerta Pharma (European R&D centre of AstraZeneca in Oss) we have a position available for a strong, motivated, and creative Senior Research Scientist with a proven track record in...

  • Scientist, Genomics Assay Development

    7 days ago

    Boston, United States Volta Labs, Inc. Full time

    ABOUT US:At Volta Labs, we are revolutionizing the future of genomics. We are a Boston based, venture–backed biotech startup that makes extracting vital information from biological samples is as simple as pressing a button, through our flagship product Callisto. Our product speeds up processing time for scientists and increases accessibility to important...

  • Scientist II/Senior Scientist, RNA Chemistry

    3 months ago

    Boston, United States NextRNA Therapeutics Full time

    About the Company: NextRNA Therapeutics, Inc. is a Boston-based biotechnology company leading the next revolution of RNA-directed therapeutics. Our focus is on identifying and drugging long non-coding RNAs (lncRNAs) with small molecules in oncology and neuroscience.Our proprietary computational engine, combined with deep lncRNA biology expertise and strong...

  • Scientist / Senior Scientist

    2 months ago

    Boston, United States Elektrofi Full time

    Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated with intravenously biologic therapies by enabling convenient at-home subcutaneous self-administration.Elektrofi is looking for a Translational Scientist/ Senior Scientist to support the development of the novel Elektrofi formulation platform.The...

  • Scientist / Senior Scientist

    2 months ago

    Boston, Massachusetts, United States Elektrofi Full time

    Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated with intravenously biologic therapies by enabling convenient at-home subcutaneous self-administration.Elektrofi is looking for a Translational Scientist/ Senior Scientist to support the development of the novel Elektrofi formulation platform.The...

  • Junior Analytical Scientist

    1 week ago

    Boston, Massachusetts, United States Elektrofi Inc Full time

    Job OverviewABOUT ELEKTROFIElektrofi is at the forefront of transforming the administration of biologic therapies, empowering patients with the choice of how they receive essential medications. Our innovative ultra-high concentration microparticle technology addresses the challenges of traditional intravenous biologic therapies, facilitating convenient...

  • Scientist or Senior Scientist

    1 day ago

    Boston, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are seeking an experienced and driven Scientist/Sr. Scientist with a deep...

  • Scientist or Senior Scientist

    15 hours ago

    boston, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are seeking an experienced and driven Scientist/Sr. Scientist with a deep...

  • Junior Analytical Scientist

    2 weeks ago

    Boston, Massachusetts, United States Elektrofi Inc Full time

    Job OverviewABOUT ELEKTROFIElektrofi is at the forefront of transforming the administration of biologic therapies, empowering patients with the choice of how they receive essential medications. Our innovative ultra-high concentration microparticle technology addresses the challenges associated with traditional intravenous biologic therapies, facilitating...

  • Senior Scientist – Pancreatic Cell Biology and Diabetes Research

    4 weeks ago

    Boston, United States FluidForm Bio Full time

    Job DescriptionSenior Scientist – Pancreatic Cell Biology and Diabetes ResearchPosition Overview:The Senior Scientist will play a crucial role in advancing our research and development efforts in the engineering and testing of 3D pancreatic tissue for the treatment of type 1 diabetes (T1D). The ideal candidate will have a robust background in pancreatic...

  • Senior Scientist – Pancreatic Cell Biology and Diabetes Research

    2 weeks ago

    Boston, United States FluidForm Bio Full time

    Job DescriptionSenior Scientist – Pancreatic Cell Biology and Diabetes ResearchPosition Overview:The Senior Scientist will play a crucial role in advancing our research and development efforts in the engineering and testing of 3D pancreatic tissue for the treatment of type 1 diabetes (T1D). The ideal candidate will have a robust background in pancreatic...

  • Junior Analytical Scientist

    1 week ago

    Boston, Massachusetts, United States Elektrofi Inc Full time

    Job OverviewABOUT ELEKTROFIElektrofi is at the forefront of transforming the administration of biologic therapies, empowering patients with the choice of how they receive essential medications. Our innovative ultra-high concentration microparticle technology addresses the challenges associated with traditional intravenous biologic therapies, facilitating...

  • Senior Scientist

    1 week ago

    Boston, United States Pivot Search Full time

    Senior Scientist - Cell-Based and Molecular Biology ServicesLocation: Boston, MAAbout My Client: My client is a leading bioanalytical Contract Research Organization (CRO) dedicated to delivering projects with unmatched quality, scientific rigor, and efficiency. With a robust history of over 30 years in the industry, they excel in the development,...

  • Senior Scientist

    1 week ago

    Boston, United States Pivot Search Full time

    Senior Scientist - Cell-Based and Molecular Biology ServicesLocation: Boston, MAAbout My Client: My client is a leading bioanalytical Contract Research Organization (CRO) dedicated to delivering projects with unmatched quality, scientific rigor, and efficiency. With a robust history of over 30 years in the industry, they excel in the development,...

  • Associate Analytical Scientist

    2 months ago

    Boston, United States Elektrofi Inc Full time

    Job DescriptionJob DescriptionDescription:ABOUT ELEKTROFIElektrofi is revolutionizing the delivery of biologic therapies by giving patients the ability to control how they want to receive and benefit from life-changing medicines. Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated with intravenously...

  • Senior Scientist, Analytical Development

    4 weeks ago

    Boston, United States Elektrofi Inc Full time

    Job DescriptionJob DescriptionDescription:ABOUT ELEKTROFI Elektrofi is revolutionizing the delivery of biologic therapies by giving patients the ability to control how they want to receive and benefit from life-changing medicines. Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated with...