Sr. Scientist, Immunology
2 months ago
Position Overview
We are looking for a Senior or Principal Scientist to lead our Immunology and Immunoprofiling team. This team develops, validates, implements, and continuously improves cutting-edge analytical platforms to evaluate a patient’s immune status, including multi-parameter flow cytometry, and blood-based next generation DNA and RNA sequencing. This candidate will manage the immunology test portfolio, including all cell-based cytometry and NGS assays ensuring the highest standards of quality, efficiency, and innovation. This position will require a deep understanding of existing and emerging immunoprofiling technologies. This candidate will need to possess exceptional operational management skills, self-motivation to drive continuous improvement in a dynamic, fast-paced environment, and serve as a critical immunology product development driver. The candidate will supervise all blood-based assays used for clinical trial support, academic collaborations, and fee-for-service projects.
Key Responsibilities:
Flow Cytometry Assay Development & Quality Control
- Assist in the development, optimization, and standardization of flow cytometry assays for the analysis of immune cell populations from patient blood and PBMCs.
- Uphold stringent quality control and quality assurance protocols to ensure consistency and reproducibility in flow cytometry data.
- Evaluate and monitor performance metrics to maintain the highest quality of data, ensuring reliable and actionable insights for immunological studies.
- Troubleshoot and resolve technical issues related to flow cytometry instrumentation and protocols to minimize operational downtime and enhance lab efficiency.
Technology and Innovation in Immunology, Immuno-Oncology, and Flow Cytometry
- Stay current with advancements in immunology, immuno-oncology, flow cytometry, and cell-focused technologies.
- Collaborate with R&D leadership to assess, implement, and validate new methodologies to maintain a leading edge in immunological research and clinical trial support.
- Drive continuous improvement and analytical validation of flow cytometry platforms and methods to ensure top-tier performance in clinical and research settings.
Cross-Functional Collaboration
- Collaborate with internal teams, including clinical operations, bioinformatics, and other R&D platforms, to support the integration and deployment of flow cytometry assays in commercial and research projects.
- Work closely with external partners, vendors, and regulatory bodies as necessary to ensure alignment with industry standards and compliance requirements.
- Partner with project management and alliance teams to define project scope, assess feasibility, and ensure alignment with company goals.
Leadership and Strategy
- Execute strategic plans for NGS operations to support the company’s NGS product portfolio, support clinical trials, collaborations, and internal R&D assay development.
- Lead, mentor, and manage a high-performing team of scientists, laboratory technicians, and bioinformaticians.
- Foster a culture of innovation, collaboration, and excellence within the NGS teams in the BG laboratory.
Budget and Resource Management
- Oversee budgeting for immunology assay development and process improvements, ensuring efficient use of resources.
- Manage procurement, inventory, and maintenance of flow cytometry equipment and reagents to support lab operations and control costs.
- Implement cost-saving measures without compromising data integrity or assay quality.
Preferred Skills:
Flow Cytometry Expertise:
- Extensive experience with multi-parameter flow cytometry, including panel design, cell sorting, data analysis, and interpretation of immune cell populations.
Immunology & Immuno-oncology Subject Matter Expertise:
- Deep understanding of cellular phenotypes and immunological signatures, within clinical and translational research contexts.
Assay Development & Tech Transfer:
- Proven experience designing, validating, and transferring flow cytometry and immunology assays from R&D to clinical operations teams.
Team Management & Effective Communication:
- Demonstrated ability to lead interdisciplinary teams and communicate complex data effectively in person or in writing to cross-functional teams and external stakeholders.
Adaptability & Initiative:
- Proactive, self-driven, and highly organized, with the ability to thrive in a fast-paced environment with shifting priorities.
Qualifications:
- Ph.D. in Immunology, Immuno-oncology, or a related field, with 5-10 years of experience in assay development, validation, and/or clinical biomarker discovery.
- Strong background in flow cytometry, with a history of successful application to research or clinical settings.
- Familiarity of bioinformatics tools and data analysis approaches relevant to flow cytometry and next generation sequencing-based analysis.
- Experience in a regulated lab environment (e.g., CLIA, CAP, GCLP) with knowledge of regulatory compliance for clinical trials.
- Strong leadership, communication, and interpersonal skills, with a track record of mentoring and developing scientific talent.
- Knowledge of supply chain management and cost-effective resource allocation to execute complex projects on time and within budget.
- Experience with regulatory compliance.
About BOSTONGENE:
BostonGene is pioneering the development of AI-driven biomedical software for the analysis of multi-omic data from cancer patients on the individual and cohort level. To support this mission, we have a cutting-edge high-complexity molecular laboratory that generates large volumes of high quality data, and a state-of-the-art dry lab staffed by an unparalleled team of data scientists and bioinformaticians. This service is used by our biopharma partners to provide custom solutions for clinical trials; from biomarker discovery to companion diagnostic development. We provide immediate diagnostic solutions for clinicians, such as our Tumor PortraitTM test to tailor optimal treatment strategies to improve cancer patient outcomes.
-
Sr. Scientist, Immunology
2 months ago
waltham, United States BostonGene Full timePosition OverviewWe are looking for a Senior or Principal Scientist to lead our Immunology and Immunoprofiling team. This team develops, validates, implements, and continuously improves cutting-edge analytical platforms to evaluate a patient’s immune status, including multi-parameter flow cytometry, and blood-based next generation DNA and RNA sequencing....
-
Principal Scientist, Immunology
1 month ago
Waltham, United States Upstream Bio Full timePosition Summary: The Principal Scientist, Immunology & Inflammation will have a broad knowledge of inflammatory diseases with demonstrated ability to provide insights into biological pathways driving inflammation. The role requires experience managing CROs to achieve departmental objectives. Excellent written and oral communication skills are required, as...
-
Waltham, United States Biocytogen Full timePosition Summary:The primary responsibilities of the Research Scientist will be to develop and perform in vitro and ex vivo cellular and/or biochemical assays and expand the company’s assay capabilities in immunology, immuno-oncology, and oncology. In addition, the incumbent will assist and support in vivo pharmacological studies using animal models,...
-
Waltham, United States AstraZeneca Full timeAstraZeneca is a global biopharmaceutical company that is dedicated to discovering, crafting, and delivering innovative medicines and healthcare solutions that improve the lives of patients. The vision of AstraZeneca Early Respiratory & Immunology (Early R&I) is centered on delivering life-changing products that advance world health and help fight and cure...
-
Upstream Bio | Principal Scientist, Immunology
1 month ago
waltham, United States Upstream Bio Full timePosition Summary: The Principal Scientist, Immunology & Inflammation will have a broad knowledge of inflammatory diseases with demonstrated ability to provide insights into biological pathways driving inflammation. The role requires experience managing CROs to achieve departmental objectives. Excellent written and oral communication skills are required, as...
-
Waltham, United States AbbVie Full timeCompany DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services...
-
Translational Research Immunology Expert
2 weeks ago
Waltham, Massachusetts, United States AbbVie Full timeJob SummaryWe are seeking a highly motivated and creative Principal Scientist to join our Precision Medicine Translational Research Immunology Group at AbbVie. The successful candidate will provide leadership in clinical biomarker strategy and assay development in inflammatory/autoimmune disease areas.Key Responsibilities:Lead cross-functional teams to...
-
Waltham, United States AbbVie Full timeJob DescriptionJob DescriptionCompany DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and...
-
Immunology Biomarker Strategist
3 weeks ago
Waltham, Massachusetts, United States AbbVie Full timeAbout This RoleWe are seeking an accomplished Principal Scientist to lead our efforts in translational medicine, focusing on rheumatological diseases such as RA, SLE, and SSc. If you have a passion for immunology and experience in developing clinical biomarkers, this could be the perfect opportunity for you.Key Responsibilities:Develop and execute clinical...
-
Waltham, United States Biocytogen Full timePosition Summary:Biocytogen is seeking highly skilled and motivated scientists to join our antibody discovery team. This role is dedicated to optimizing therapeutic antibody binders from our RenBiologics program, which generates an extensive library of therapeutic antibodies targeting thousands of druggable genes. The successful candidate will utilize...
-
waltham, United States Biocytogen Full timePosition Summary:Biocytogen is seeking highly skilled and motivated scientists to join our antibody discovery team. This role is dedicated to optimizing therapeutic antibody binders from our RenBiologics program, which generates an extensive library of therapeutic antibodies targeting thousands of druggable genes. The successful candidate will utilize...
-
Scientist for in vitro Pharmacology
4 months ago
waltham, United States Biocytogen Full timePosition Summary:The primary responsibilities of the Research Scientist will be to develop and perform in vitro and ex vivo cellular and/or biochemical assays and expand the company’s assay capabilities in immunology, immuno-oncology, and oncology. In addition, the incumbent will assist and support in vivo pharmacological studies using animal models,...
-
Scientist for in vitro Pharmacology
4 months ago
Waltham, United States Biocytogen Full timePosition Summary:The primary responsibilities of the Research Scientist will be to develop and perform in vitro and ex vivo cellular and/or biochemical assays and expand the company’s assay capabilities in immunology, immuno-oncology, and oncology. In addition, the incumbent will assist and support in vivo pharmacological studies using animal models,...
-
Medical Research Scientist for Rare Diseases
4 weeks ago
Waltham, Massachusetts, United States Lifelancer Full timeAbout UsLifelancer is a leading talent-hiring platform in Life Sciences, Pharma, and IT. We connect talented professionals with opportunities in pharma, biotech, health sciences, healthtech, and IT domains.Job DescriptionJob Title: Medical Research Scientist for Rare DiseasesLocation: United States (Remote or Hybrid)Contract Type: Full-timeSeniority Level:...
-
Research Associate in Waltham, MA
7 days ago
Waltham, United States Rangam Full timePay Scale: $65-$69 per hourLocation: Waltham, MA (100% onsite)M-F 9:00 AM-5:00 PM ESTCandidates that have served as a Scientist or Senior Scientist would be considered overqualified.Must have Experience:Bachelor’s degree with minimum of 4 year of Research Associate related experience.Expertise with mammalian cell culture including sterile technique, line...
-
Research Associate in Waltham, MA
7 days ago
Waltham, United States Rangam Full timePay Scale: $65-$69 per hourLocation: Waltham, MA (100% onsite)M-F 9:00 AM-5:00 PM ESTCandidates that have served as a Scientist or Senior Scientist would be considered overqualified.Must have Experience:Bachelor’s degree with minimum of 4 year of Research Associate related experience.Expertise with mammalian cell culture including sterile technique, line...
-
Precision Medicine Scientist Lead
2 weeks ago
Waltham, Massachusetts, United States AbbVie Full timeJob DescriptionWe are seeking a highly skilled and experienced Principal Scientist to join our team at AbbVie. As a key member of our Precision Medicine Translational Research Immunology Group, you will play a critical role in developing and executing our translational research strategies.Responsibilities:Design and implement clinical biomarker strategies to...
-
Principal Scientist, Bioanalytical Scientist
3 months ago
Waltham, United States Upstream Bio Full timePosition Summary:Upstream Bio seeks a Principal Scientist, Bioanalytical Sciences who will lead the development and implementation of critical bioassays to support development programs and provide scientific and operational oversight of bioanalytical sample analyses.The ideal candidate will represent the Bioanalytical function on cross-functional project...
-
Principal Scientist, Bioanalytical Scientist
3 months ago
waltham, United States Upstream Bio Full timePosition Summary:Upstream Bio seeks a Principal Scientist, Bioanalytical Sciences who will lead the development and implementation of critical bioassays to support development programs and provide scientific and operational oversight of bioanalytical sample analyses.The ideal candidate will represent the Bioanalytical function on cross-functional project...
-
Principal Scientist, Bioanalytical Scientist
3 months ago
Waltham, United States Upstream Bio Full timePosition Summary:Upstream Bio seeks a Principal Scientist, Bioanalytical Sciences who will lead the development and implementation of critical bioassays to support development programs and provide scientific and operational oversight of bioanalytical sample analyses.The ideal candidate will represent the Bioanalytical function on cross-functional project...
