Immunology Biomarker Strategist

4 days ago


Waltham, Massachusetts, United States AbbVie Full time
About This Role

We are seeking an accomplished Principal Scientist to lead our efforts in translational medicine, focusing on rheumatological diseases such as RA, SLE, and SSc. If you have a passion for immunology and experience in developing clinical biomarkers, this could be the perfect opportunity for you.

Key Responsibilities:

  • Develop and execute clinical biomarker strategies to support human dose projection and establish early signs of efficacy in clinical trials.
  • Collaborate with Data Science team and Precision Medicine lead to analyze internal and external omics data, understand heterogeneity of diseases, identify disease endotypes, and generate patient selection and combination hypotheses for further testing.
  • Develop preclinical patient derived disease models, design studies with appropriate controls and endpoints to understand drug target mechanisms for PD biomarker development.
  • Serve as a subject matter expert in analytical methodologies/technologies for translational research including single cell and spatial omics, proteomics, methylomics, metabolomics, genomics, NGS, MSD, ELISA, Luminex, flow cytometry, ex vivo primary cell culture and organoid-immune cell culture.
  • Manage external CROs and academic collaborations including study proposal, budget, timeline, and data review.

About Us:

AbbVie is a global leader in developing innovative medicines and solutions that improve patients' lives. With a rich history of scientific innovation and a commitment to excellence, we continue to push the boundaries of what is possible in the field of biopharmaceuticals.



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