Scientist/Sr. Scientist-Preclinical Antibody Drug Development

6 days ago

Waltham, United States Biocytogen Full time

Position Summary:

Biocytogen is seeking highly skilled and motivated scientists to join our antibody discovery team. This role is dedicated to optimizing therapeutic antibody binders from our RenBiologics program, which generates an extensive library of therapeutic antibodies targeting thousands of druggable genes. The successful candidate will utilize advanced antibody engineering techniques to improve binding affinity, specificity, stability, and therapeutic functionality. This work supports the development of antibodies across diverse therapeutic areas, including immuno-oncology, inflammatory and autoimmune diseases, neurology, cardiovascular conditions, and metabolic disorders.


Job Responsibilities:

Target Selection and Program Design

  • Select and evaluate therapeutic targets with a strong understanding of MOA, druggability, and delivery options.
  • Design experimental strategies to advance candidates from Biocytogen’s RenBiologics Antibody Binder/Lead Library toward therapeutic development.

Project Management

  • Drive projects by assembling resources, managing timelines, and ensuring alignment with program objectives.

Antibody Engineering and Optimization

  • Engineer antibodies to improve affinity, specificity, stability, and manufacturability.
  • Optimize antibodies through advanced molecular designs, such as Fc engineering or bispecific formats.

Lead Evaluation and Development

  • Evaluate lead antibodies for binding, function, and developability, ensuring readiness for preclinical development.

Collaboration and Reporting

  • Work with discovery, manufacturing, and BD licensing teams to advance and out-license antibody assets.
  • Maintain clear documentation and present findings to internal and external stakeholders.


Required Skills and Experience:

  • PhD in Biochemistry, Molecular Biology, Immunology, or a related field with 2+ years of relevant experience, or MS with 5+ years of experience in antibody engineering and project management.
  • Strong expertise in target biology research, including understanding MOA, druggability, and formulation requirements.
  • Proven experience in antibody engineering and optimization, including affinity maturation and stability improvement.
  • Demonstrated ability to independently drive projects, assemble resources, and meet critical milestones.
  • Excellent collaboration and communication skills for working with cross-functional teams and presenting findings effectively.


BIOCYTOGEN is an Equal Opportunity Employer. Employment opportunities at BIOCYTOGEN BOSTON CORP are based upon one’s qualifications and capabilities to perform the essential functions of a particular job. All employment opportunities are provided without regard to race, color religion, sex, national origin, ancestry, age, sexual orientation, gender identity and expression, veteran status, military status, disability, mental illness, genetic information, or any other characteristic protected by law. This Equal Employment Opportunity policy governs all aspects of employment, including, but not limited to, recruitment, hiring, selection, job assignment, promotions, transfers, compensation, discipline, termination, layoff, access to benefits and training, and all other conditions and privileges of employment.

  • Biocytogen | Scientist/Sr. Scientist-Preclinical Antibody Drug Development

    5 days ago

    waltham, United States Biocytogen Full time

    Position Summary:Biocytogen is seeking highly skilled and motivated scientists to join our antibody discovery team. This role is dedicated to optimizing therapeutic antibody binders from our RenBiologics program, which generates an extensive library of therapeutic antibodies targeting thousands of druggable genes. The successful candidate will utilize...

  • Associate Scientist

    7 months ago

    Waltham, United States Abcam Full time

    Company Description For over 20 years, abcam has been providing tools the scientific community needs to enable faster breakthroughs in critical areas like cancer, neurological disorders, infectious diseases, and metabolic disorders. We believe that to continue making progress, we need to work together in new ways. We need your own unique perspective...

  • Senior Data Scientist, Translational Medicine

    6 days ago

    Waltham, United States ZipRecruiter Full time

    Job DescriptionJob DescriptionSalary: Summary Visterra is seeking a highly motivated and skilled Data Scientist or Senior Data Scientist (commensurate with experience) to join our Translational team. This individual will play a critical role in exploratory translational data analysis, visualization, interpretation, and documentation, supporting our...

  • Senior Scientist, Immunology

    2 months ago

    Waltham, United States Upstream Bio Full time

    Position Summary: The Sr. Scientist, Immunology & Inflammation will have a broad knowledge of inflammatory diseases with demonstrated ability to provide insights into biological pathways driving inflammation. The role requires experience managing CROs to achieve departmental objectives. Excellent written and oral communication skills are required, as is the...

  • Senior Scientist, Immunology

    2 months ago

    waltham, United States Upstream Bio Full time

    Position Summary: The Sr. Scientist, Immunology & Inflammation will have a broad knowledge of inflammatory diseases with demonstrated ability to provide insights into biological pathways driving inflammation. The role requires experience managing CROs to achieve departmental objectives. Excellent written and oral communication skills are required, as is the...

  • Senior Scientist, Immunology

    2 months ago

    Waltham, United States Upstream Bio Full time

    Position Summary: The Sr. Scientist, Immunology & Inflammation will have a broad knowledge of inflammatory diseases with demonstrated ability to provide insights into biological pathways driving inflammation. The role requires experience managing CROs to achieve departmental objectives. Excellent written and oral communication skills are required, as is the...

  • Senior Scientist, Immunology

    2 months ago

    waltham, United States Upstream Bio Full time

    Position Summary: The Sr. Scientist, Immunology & Inflammation will have a broad knowledge of inflammatory diseases with demonstrated ability to provide insights into biological pathways driving inflammation. The role requires experience managing CROs to achieve departmental objectives. Excellent written and oral communication skills are required, as is the...

  • Principal Scientist, Bioanalytical Scientist

    2 months ago

    Waltham, United States Upstream Bio Full time

    Position Summary:Upstream Bio seeks a Principal Scientist, Bioanalytical Sciences who will lead the development and implementation of critical bioassays to support development programs and provide scientific and operational oversight of bioanalytical sample analyses.The ideal candidate will represent the Bioanalytical function on cross-functional project...

  • Principal Scientist, Bioanalytical Scientist

    2 months ago

    waltham, United States Upstream Bio Full time

    Position Summary:Upstream Bio seeks a Principal Scientist, Bioanalytical Sciences who will lead the development and implementation of critical bioassays to support development programs and provide scientific and operational oversight of bioanalytical sample analyses.The ideal candidate will represent the Bioanalytical function on cross-functional project...

  • Principal Scientist, Bioanalytical Scientist

    2 months ago

    Waltham, United States Upstream Bio Full time

    Position Summary:Upstream Bio seeks a Principal Scientist, Bioanalytical Sciences who will lead the development and implementation of critical bioassays to support development programs and provide scientific and operational oversight of bioanalytical sample analyses.The ideal candidate will represent the Bioanalytical function on cross-functional project...

  • Principal Scientist, Bioanalytical Scientist

    2 months ago

    waltham, United States Upstream Bio Full time

    Position Summary:Upstream Bio seeks a Principal Scientist, Bioanalytical Sciences who will lead the development and implementation of critical bioassays to support development programs and provide scientific and operational oversight of bioanalytical sample analyses.The ideal candidate will represent the Bioanalytical function on cross-functional project...

  • Principal Scientist, Computational Biotherapeutics Engineering

    1 month ago

    Waltham, United States Xilio Therapeutics Full time

    Principal Scientist, Computational Biotherapeutics Engineering Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using...

  • Principal Scientist, Computational Biotherapeutics Engineering

    1 month ago

    Waltham, United States Atlas Venture Full time

    Principal Scientist, Computational Biotherapeutics EngineeringCompany Address: 828 Winter St, Waltham, Massachusetts 02451, US About Xilio TherapeuticsFocused on harnessing the immune system to achieve deep and durable clinical responses to improve the lives of patients.Job DescriptionXilio Therapeutics is a clinical-stage biotechnology company discovering...

  • Senior Scientist

    2 weeks ago

    Waltham, MA, United States Xilio Therapeutics Full time

    Senior Scientist / Principal Scientist, Biotherapeutic Engineering Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is...

  • Pharmacovigilance Scientist

    2 days ago

    Waltham, United States Dyne Tx Full time

    Our commitment to people with muscle diseases is our greatest strength.Director, Drug Safety & Pharmacovigilance ScientistDyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE platform, Dyne is developing modern...

  • Principal Scientist, Bioinformatics Data Science

    1 month ago

    Waltham, United States Atlas Venture Full time

    Principal Scientist, Bioinformatics Data ScienceCompany Address: 1560 Trapelo Rd, Waltham, Massachusetts 02451, US About Dyne TherapeuticsDyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases.Job DescriptionThe Principal Scientist,...

  • Data Scientist in Translational Medicine

    5 days ago

    Waltham, Massachusetts, United States ZipRecruiter Full time

    About the RoleWe are seeking a highly skilled Data Scientist to join our Translational team. This individual will play a critical role in exploratory translational data analysis, visualization, interpretation, and documentation, supporting our clinical programs.Key ResponsibilitiesConduct comprehensive data analyses using statistical methods and data...

  • Senior Scientist, Immunology

    4 weeks ago

    Waltham, United States Upstream Bio Full time

    Position Summary:The Senior Scientist, Immunology & Inflammation will have a broad knowledge of inflammatory diseases with demonstrated ability to provide insights into biological pathways driving inflammation. The role requires experience managing CROs to achieve departmental objectives. Excellent written and oral communication skills are required, as is...

  • Senior Scientist, Immunology

    4 weeks ago

    Waltham, United States Upstream Bio Full time

    Position Summary:The Senior Scientist, Immunology & Inflammation will have a broad knowledge of inflammatory diseases with demonstrated ability to provide insights into biological pathways driving inflammation. The role requires experience managing CROs to achieve departmental objectives. Excellent written and oral communication skills are required, as is...

  • Principal Scientist, Immunology

    3 weeks ago

    Waltham, United States Upstream Bio Full time

    Position Summary: The Principal Scientist, Immunology & Inflammation will have a broad knowledge of inflammatory diseases with demonstrated ability to provide insights into biological pathways driving inflammation. The role requires experience managing CROs to achieve departmental objectives. Excellent written and oral communication skills are required, as...