Senior Scientist

4 weeks ago


South San Francisco, United States BEPC Inc. - Business Excellence Professional Consulting Full time

BEPC has an open position for a Scientist 1 (Protein Expression and Purification, Contract role)

Contract W2 Period: 12-month contract with possibilities for extensions

Pay & Benefits: $43-$50/hr. + Medical, Dental, Vision and Life Insurance



The departments of BioMolecular Research and Structural Biology, within the Protein Sciences

organization at Genentech are looking for a versatile, dynamic, self-motivated individual to join us as a Scientist 1. The selected individual will contribute towards recombinant

protein expression and purification efforts to support drug discovery activities. This role will

facilitate expression analysis of novel protein encoding constructs, by building, developing and

utilizing automated high throughput processes for expression, purification and characterization

for research and portfolio projects. The qualified candidate must be technically strong, self-

driven, passionate about science, results and detail oriented. In this collaborative role, the

successful candidate will have the opportunity to work with other scientists and group leaders

within and outside our department to fulfill protein production needs. This is an on-site role

based in South San Francisco, CA.

Job Responsibilities

Protein purification using a variety of chromatographic techniques (affinity, size

exclusion, ion exchange) for structural and biochemical studies

Screening and optimizing expression and purification of challenging membrane proteins

using detergent lysis

Using various expression platforms such as E.coli, insect cells (BEVS), and mammalian

expression platforms for small and medium scale protein production

Performing SDS-PAGE, western blot, protein characterization assays by different

biophysical and biochemical methods

Operating and maintaining High performance liquid chromatography systems (HPLC) for

protein purification and analysis

Performing gel analysis, capturing and interpreting data, uploading results to LIMS

databases and sharing with stakeholders

Communicating with and presenting to collaborators and stakeholders across the Protein

Sciences organization

Required qualifications

Applicants with a Masters degree in the Biological Sciences should have at least 3-4

years of scientific experience and applicants with a PhD degree (Biochemistry,

Biophysics, Cell Biology, Molecular Biology) should have at least 1-2 years of relevant

experience

Strong protein purification expertise in affinity and size exclusion chromatography

Strong aseptic cell culture techniques for handling routinely insect and mammalian cells

Ability to think critically, analyze results, plan experiments and carry out troubleshooting

as needed

Strong desire to learn new techniques, advance technologies related to protein

optimization and interest in implementing new expression systems.

Demonstrated ability to work independently in a team-oriented setting

Expertise with automation and high-throughput process development will be a plus

Excellent verbal and written communication skills

Excellent organizational skills


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