[Senior] Scientist

3 weeks ago

South San Francisco, United States Y-Trap Full time
Job DescriptionJob DescriptionY-Trap is seeking a highly motivated and fast-moving [Senior] Scientist – Immunology, who will be responsible for design and hands-on execution of in vitro experiments to advance the discovery and development of multifunctional fusion proteins for cancer immunotherapy.

About us: Y-Trap is a startup in South San Francisco developing novel fusion proteins for cancer immunotherapy, founded by Johns Hopkins and Stanford scientists. While current immunotherapies aim to activate and expand T cells by blocking immune checkpoints, they do not correct the immunosuppressive & tumor-promoting phenotypes of immune cells that dominate in the tumor. Y-Trap has utilized its versatile computational engineering platform to develop a portfolio of antibody-ligand traps (“Y-traps”) designed to counteract the determinants of these tumor-promoting immune cell phenotypes. Y-Trap is currently advancing its lead programs towards first-in-human clinical studies. 

In this role, you will:
  • Independently design, execute, and interpret experiments to support the development of immuno-modulating fusion proteins. 
  • Support the management of outsourced activities such as protein expression and in vivo toxicology.
  • Support wet-lab protein engineering efforts.
We are seeking an exceptional candidate with the following qualifications:
  • Strong expertise in a variety of immunological assays, cell culture and immune cell characterization. You love being in the lab and are great at flow cytometry. You're comfortable generating reporter cell lines, running an ELISA, and bringing a new assay online. 
  • Self-driven and resourceful. You're excited to learn new skills when needed, with a mentality to do whatever it takes to get the job done in a small team with a lot of autonomy.
  • You may have a PhD in immunology (or a related field), or have gained equivalent experience working in industry.
Ideally, you may also have one or more of the following:
  • Experience accomplishing the above objectives in a fast-paced startup environment.
  • Experience with protein engineering techniques (e.g., yeast display).
  • Knowledge of biologics drug development, such as managing outsourced IND-enabling toxicology studies.

Y-Trap is based in South San Francisco, CA and offers competitive salary, benefits, and stock options. This is not an entry-level position, but candidates of varying seniority are encouraged to apply. Seniority and compensation will be commensurate to experience.

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