Principal Scientist, Biology

2 weeks ago

San Diego, United States RayzeBio Full time

Job Title: Principal Scientist, Biology

Location: San Diego

NH: R6


Background

RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.


Job Description

The role offers an opportunity to take a leadership role in defining and implementing the biology strategy for the pipeline projects from target selection through candidate nomination stages. The ideal candidate will be an experienced, accomplished biologist with outstanding interpersonal and communication skills. The role with work closely with leadership team to develop and execute overall project strategy, including forecasting resource needs and ensuring deliverables are met under tight timelines. The position will require an ability to work effectively in interdisciplinary team settings and is expected to supervise and guide junior team members. In addition to being a thought leader this role is expected to provide technical leadership in the lab as pertains to developing, validating, and executing in vitro assays, developing oncology models to support the project needs. The role requires an ability and willingness to work with radioactive isotopes.


Job Responsibilities

• Utilize a deep understanding of cancer biology and oncology drug development to lead the efforts on target selection and initiation of new RPT projects.

• In partnership with a cross functional team leader provide strategic and operational leadership for project teams on specific targets.

• Work in close collaboration with interdisciplinary teams to provide functional biology leadership to guide programs through lead identification/optimization phases.

• Help with the generation of preclinical GLP/non-GLP data packages in support of regulatory submissions and clinical development.

• Help with the formulation of a translational biology plan to support the clinical development strategy.

• Author/review study reports and regulatory documentation, scientific presentations and publications manage external research collaborations.

• Assess scientific and research needs for a project and engage with external partners, KOLs and set up external partnerships as needed.

• Serve as the scientific lead for external partnerships, collaborations and lead scientific projects through outsourcing if needed.

• Effectively manage internal, external resources and budgets in support of corporate goals


Education and Experience

• PhD or BS in cancer biology, cell biology, pharmacology, or a related field and a deep understanding of cancer biology and experience working in oncology drug development is ideal.

• PhD 4+ years or BS 8+ years of experience in pharmaceutical/biotech R&D environments demonstrating successful accomplishments and progressive leadership and broadening responsibilities.

• Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable.

Skills and Qualifications

• Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.

• Strong interpersonal, organizational and communication skills and ability to motivate and drive productivity in small company environments. Prior experience as a project leader or functional leader on interdisciplinary team is critical.

• Strong Expertise with invitro, cell-based assay development and optimization and proficiency with Cell culture, molecular biology techniques, ELISA, flow-cytometry, western blot, qPCR, single-cell cloning, immunohistochemistry and related protocols.

• Familiarity with ADME/PK concepts and drug development process and interfacing with regulatory teams would be desirable.

• Familiarity with the development and use of in vivo oncology models is critical as is the ability to design and supervise appropriately controlled in vivo experiments.

• Ability to effectively partner with Clinical, regulatory, CMC and chemistry/DMPK teams and successfully lead interdisciplinary scientific teams and experience in mentoring and managing work of junior scientists.

• Ability to work with radioisotopes with strict adherence to radiation safety protocols.

• Ability to successfully establish and manage external collaborations including CROs and academic and industrial partnerships.

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