Current jobs related to Senior Scientist, Discovery Biology - San Diego - Light Horse Therapeutics
-
Senior Protein Scientist
1 week ago
San Diego, California, United States Treeline Biosciences Full timeJob SummaryTreeline Biosciences is seeking a highly experienced Senior Protein Scientist to join our Protein Sciences team. As a key member of our early-stage discovery programs, you will play a critical role in supporting the development of new medicines against challenging molecular targets in oncology.Key ResponsibilitiesDevelop and implement strategies...
-
Senior Researcher, Discovery Biology
2 weeks ago
South San Francisco, California, United States Biogen Full timeAbout the RoleWe are seeking a highly motivated Research Scientist to join our team at Biogen, a leading biotechnology company. As a Senior Researcher, you will play a key role in driving the discovery and validation of novel therapeutic targets in autoimmune and inflammatory diseases.Key ResponsibilitiesDesign and execute experiments to establish...
-
Senior Computational Biology Scientist
3 weeks ago
San Diego, California, United States Genesis Therapeutics Inc. Full timeAbout Genesis TherapeuticsGenesis Therapeutics is at the forefront of integrating artificial intelligence with rational drug design to tackle significant unmet medical challenges. We are seeking a dedicated and versatile Senior Computational Biology Scientist to join our dynamic team in a stimulating biotech setting.Position OverviewThis full-time role...
-
San Diego, California, United States AlivaMab Discovery Services Full timeUnlock the Potential of Next-Generation SequencingAlivaMab Discovery Services is seeking a highly skilled Senior Scientist to join our Antibody Engineering Team. As a key member of our team, you will be responsible for developing and implementing next-generation sequencing (NGS) workflows to enable antibody discovery and engineering projects. Your expertise...
-
Senior Principal Scientist-Tumor Biology
4 days ago
San Diego, California, United States Pfizer Full timeROLE SUMMARYThe primary focus of this position is to translate fundamental discoveries in cancer epigenetics and oncogenic transcriptional programming into novel therapeutic approaches.Key ResponsibilitiesConduct biology discovery to support existing and emerging drug discovery programs in the Tumor Biology group.Lead a team of scientists to perform...
-
Senior Protein Scientist
7 days ago
San Diego, California, United States Treeline Biosciences Full timeUnlock the Potential of Protein Sciences at Treeline BiosciencesWe are seeking a highly skilled Senior Protein Scientist to join our Protein Sciences team at Treeline Biosciences. As a key member of our team, you will play a critical role in supporting early-stage discovery programs by collaborating closely with a cross-functional team of scientists to...
-
San Diego, United States Bristol Myers Squibb Full timePrincipal Scientist, Membrane Protein Structural BiologyBMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases.Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale...
-
Senior Data Scientist
3 weeks ago
San Diego, California, United States Society of Exploration Geophysicists Full timeAbout the RoleWe are seeking a highly skilled Senior Data Scientist to join our team at the Society of Exploration Geophysicists. As a key member of our data science team, you will play a critical role in driving our target discovery efforts forward.Key ResponsibilitiesCollaborate with Cross-Functional Teams: Work closely with human geneticists, biologists,...
-
Senior Protein Scientist
7 days ago
San Diego, California, United States Treeline Biosciences Full timeUnlock the Potential of Protein Sciences at Treeline BiosciencesWe are seeking a highly skilled and experienced Senior Protein Scientist to join our Protein Sciences team at Treeline Biosciences. As a key member of our team, you will play a critical role in supporting early-stage discovery programs by collaborating closely with a cross-functional team of...
-
San Diego, California, United States Bristol Myers Squibb Full timeJob SummaryBristol Myers Squibb is a leader in the discovery and development of novel therapies that exploit targeted protein degradation. As a Senior Scientist, Membrane Protein Structural Biology Expert, you will play a critical role in our efforts to understand mechanisms of action, design ligands or drug molecules, and make predictions about new...
-
Senior Research Associate, Discovery Biology
2 weeks ago
san diego, United States Light Horse Therapeutics Full timeLight Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...
-
Senior Research Associate, Discovery Biology
2 weeks ago
San Diego, United States Light Horse Therapeutics Full timeLight Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...
-
Senior Research Associate, Discovery Biology
2 weeks ago
San Diego, United States Light Horse Therapeutics Full timeLight Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...
-
Senior Research Associate, Discovery Biology
5 days ago
San Diego, California, United States Light Horse Therapeutics Full timeJob SummaryLight Horse Therapeutics is a cutting-edge biotech company based in San Diego, leveraging innovative tools from chemical and computational biology to identify novel therapeutic targets for oncology. We are seeking a highly motivated Senior Research Associate to join our Discovery Biology team.Key ResponsibilitiesDevelop and optimize cellular...
-
Senior Vice President, Biology and Discovery
2 weeks ago
San Diego, California, United States Tentarix Biotherapeutics, Inc. Full timeAbout UsTentarix Biotherapeutics, Inc. is a pioneering biotechnology company that has developed a revolutionary platform for the discovery of next-generation, multispecific biologic drugs. Our mission is to make a significant difference in the lives of patients suffering from cancer or autoimmune diseases.Our TeamWe are led by a seasoned executive team with...
-
Senior Protein Scientist
2 weeks ago
San Diego, California, United States Treelinebiosciences Full timeAbout the RoleTreeline Biosciences is a biopharmaceutical company dedicated to developing innovative medicines against challenging molecular targets in oncology. As a senior member of our Protein Sciences team, you will play a critical role in supporting early-stage discovery programs by collaborating closely with a cross-functional team of scientists to...
-
San Francisco, California, United States Tbwa ChiatDay Inc Full timeAbout the RoleWe are seeking a highly experienced and accomplished Cancer Biology and Drug Discovery Leader to join our team at General Proximity. As a key member of our Biology Team, you will play a critical role in leading and managing our research efforts, working closely with our Platform Team to develop and advance our core drug discovery technology.Key...
-
Senior Antibody Discovery Scientist
7 days ago
South San Francisco, California, United States Net2Source Inc. Full timeJob SummaryWe are seeking a highly skilled Senior Antibody Discovery Scientist to join our team at Net2Source Inc. as a Scientist Consultant, Antibody Discovery. The ideal candidate will have a strong background in antibody discovery and protein engineering, with significant experience in single B cell cloning, hybridoma, or phage/yeast display...
-
Senior Research Scientist
5 days ago
San Diego, California, United States AlivaMab Discovery Services Full timeJob DescriptionAlivaMab Discovery Services is seeking a highly skilled and experienced Senior Research Scientist to join our Antibody Engineering Team. The successful candidate will have the responsibility to support antibody discovery and engineering projects through Next-Generation Sequencing (NGS) of various samples, including hybridomas, single B-cells,...
-
Research Scientist in iPSC Biology
3 weeks ago
San Diego, California, United States Trebla Talent Full timePosition: Research Scientist/Senior Scientist, iPSC BiologyCompany Overview: Trebla Talent is collaborating with an innovative biotech firm dedicated to pioneering an AI-driven human brain organoid platform. This organization is on a mission to transform the landscape of Neuro and CNS drug development, aiming to replace traditional, costly, and inefficient...
Senior Scientist, Discovery Biology
4 months ago
Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading academics Brian Liau (Harvard), Ben Cravatt (Scripps) and Nathanael Gray (Stanford) with initial financial backing from Versant Ventures and Mubadala Capital.
Light Horse Therapeutics is seeking a talented, motivated, and creative Senior Scientist to join the Discovery Biology group. The candidate will contribute to strategy and implementation in early discovery programs for high value, challenging oncology targets. The candidate will also contribute broadly to building an understanding of novel target biology in a dynamic start-up environment that employs cutting-edge tools in functional genomics and proteomic technologies.
Job Description:
As part of a dynamic Discovery Biology group, the candidate will translate insights from our cutting-edge precision genome editing platform into small molecule discovery programs. A successful candidate will have broad knowledge of modern drug discovery techniques spanning multiple disciplines and work collaboratively across the organization. The responsibilities of the candidate include:
- Design, develop and execute screening funnels using cellular and/or biochemical assays for discovery of small molecule inhibitors for high value oncology targets
- Contribute to early discovery strategy for high value protein targets by leveraging broad knowledge and techniques across chemical, molecular and cellular biology
- Contribute to target selection and validation for the early discovery pipeline
- Develop approaches to understand the mechanistic target biology and employ innovative strategies to leverage these findings for assay development
- Communicate science and strategy effectively in internal meetings and prepare written reports of data and literature analyses
- Position requires benchwork responsibilities
Required Qualifications:
- PhD in Chemical Biology, Molecular/Cell Biology, or Biochemistry or related field with 3+ years of biopharmaceutical industry research experience.
- Practical experience with small molecule inhibitor discovery and developing medium to high-throughput in vitro and cell-based assays. Demonstrated success in leading hit-to-lead discovery programs is a plus.
- Strong experience in cell-based assay development and mechanistic target biology research. Experience in protein-protein interactions and proximity based techniques (e.g. TR-FRET, proximity ligation, nanoBRET) is an advantage.
- Expertise in transcriptional regulation is an advantage, including ChIP assays and ChiP-/ ATAC-sequencing.
- Demonstrated ability to multi-task, prioritize options, anticipate challenges and accomplish goals in a fast-paced research environment
- Management of direct reports is an advantage
- The individual should be scientifically creative and driven by a willingness to embrace innovation and an eagerness to challenge and meet aggressive timelines
- The ability to work closely with other group members within teams is essential