Sr./Principal Scientist, Translational Genetics

2 weeks ago


San Diego, United States BioPhase Full time

Sr. or Principal Scientist, Translational Genetics


The ideal candidate will apply their background and experience in genetics, molecular biology and disease pathophysiology towards both identifying novel therapeutic targets and formulating mechanistic hypotheses that can be evaluated experimentally.


Responsibilities:

The Scientist will leverage extensive human genetics data to identify and evaluate new therapeutic targets, translating these discoveries into actionable therapeutic programs.


The role will involve:

  • Designing, conducting, and interpreting human genetic analyses to uncover new therapeutic targets.
  • Utilizing both established and innovative analytical methods to identify genetic links to human health and disease.
  • Converting findings from genetic analyses into therapeutic hypotheses with sound mechanistic reasoning, supported by additional evidence and experimental validation.
  • Collaborating with interdisciplinary teams of geneticists, bioinformaticians, biologists, chemists, and drug developers to design and conduct studies (in silico, in vitro, and in vivo) that validate therapeutic hypotheses.
  • Presenting genetic discoveries through expert-level internal and external presentations and preparing manuscripts for peer-reviewed journals.
  • Contributing innovative ideas and strategic thinking to enhance the company's drug discovery platforms.
  • Staying updated with the latest developments in the genetics community and integrating relevant findings and methods into internal projects.


Qualifications:

  • A PhD in Human Genetics, Biomedical Informatics, or a related field, or a Master's degree with at least one year of experience in human genetics research focused on translational applications.
  • Proven experience in designing, leading, interpreting, and communicating human genetics studies, with an ability to identify therapeutically relevant hypotheses.
  • Strong understanding of statistical genetics and genetic epidemiology.
  • Preference for candidates with a background in molecular biology; a solid grasp of experimental study design to assess the functional impact of genetic variants and genetic associations is required. This role is not suitable for those with a primary focus on wet-lab work.


  • San Diego, United States BioPhase Full time

    Sr. or Principal Scientist, Translational Genetics The ideal candidate will apply their background and experience in genetics, molecular biology and disease pathophysiology towards both identifying novel therapeutic targets and formulating mechanistic hypotheses that can be evaluated experimentally.Responsibilities:The Scientist will leverage extensive human...

  • Principal Scientist

    4 days ago


    South San Francisco, United States Amgen Full time

    **HOW MIGHT YOU DEFY IMAGINATION?** If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies. We are global collaborators who achieve together-researching, manufacturing, and delivering ever-better...

  • Principal Scientist

    4 days ago


    South San Francisco, United States Amgen Inc. Full time

    JOB ID: R-182125 LOCATION: US - California - South San Francisco WORK LOCATION TYPE: On Site DATE POSTED: Feb. 22, 2024 CATEGORY: Scientific SALARY RANGE: 138,904.00 USD - 165,489.00 USD HOW MIGHT YOU DEFY IMAGINATION? If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission-to serve patients-drives all that we...

  • Principal Scientist

    4 days ago


    South San Francisco, United States Amgen Full time

    HOW MIGHT YOU DEFY IMAGINATION?If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products...

  • Principal Scientist

    4 days ago


    South San Francisco, United States BioSpace Full time

    Job DetailsHOW MIGHT YOU DEFY IMAGINATION?If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better...


  • San Francisco, United States R&D Partners Full time

    R&D Partners is seeking to hire a Senior/ Principal Scientist in Translational Medicine Mass Spectrometry (Contractor) in San Franciscon, CA. Your main responsibilities as a Senior/ Principal Scientist in Translational Medicine Mass Spectrometry (Con Scientist, Principal, Clinical Research, Spectrometry, Chemistry, Staffing


  • San Diego, United States Zentalis Full time

    Job DescriptionJob DescriptionSalary: $125-148kJOB SUMMARY: Responsible for leading research on translational projects focused on small molecule drug combinations and understanding MoA. Generate robust datasets that will have a direct impact on our oncology drug discovery process and drug pipeline.ESSENTIAL DUTIES AND RESPONSIBILITIES:Design, conduct, and...


  • San Francisco, United States Firefly Bio Full time

    About Firefly Bio: Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders. Our state-of-the-art platform results in highly specific delivery of degraders to target tissue. Our mission is to realize the full potential of ADCs by unlocking new classes of payloads. Our company...


  • South San Francisco, United States Maze Therapeutics Full time

    The Position: Translational Genomics team is looking for an exceptional Sr. Scientist in statistical genetics. Maze utilizes human genetics at all stages of drug development. You will design, lead and/or execute robust genetic association studies with the goal of identifying potential drug targets. You will also contribute to target validations and mechanism...

  • Sr. Scientist

    2 weeks ago


    San Diego, United States Meet Full time

    Meet's partnered with an exciting and growing biotech in San Diego for a Senior Scientist / Principal Scientist Analytical Development!You'll be responsible for designing, executing, and reporting on the analytical development of small molecule chemistry experiments, degradation pathways, characterization, and stabilization techniques for ophthalmic and...

  • Sr. Scientist

    4 weeks ago


    San Diego, United States Meet Full time

    Meet's partnered with an exciting and growing biotech in San Diego for a Senior Scientist / Principal Scientist Analytical Development!You'll be responsible for designing, executing, and reporting on the analytical development of small molecule chemistry experiments, degradation pathways, characterization, and stabilization techniques for ophthalmic and...

  • Sr. Scientist

    4 weeks ago


    San Diego, United States Meet Full time

    Meet's partnered with an exciting and growing biotech in San Diego for a Senior Scientist / Principal Scientist Analytical Development!You'll be responsible for designing, executing, and reporting on the analytical development of small molecule chemistry experiments, degradation pathways, characterization, and stabilization techniques for ophthalmic and...


  • South San Francisco, California, United States Maze Therapeutics Full time

    The Position:Translational Genomics team is looking for an exceptional Sr. Scientist in statistical genetics. Maze utilizes human genetics at all stages of drug development. You will design, lead and/or execute robust genetic association studies with the goal of identifying potential drug targets. You will also contribute to target validations and mechanism...


  • San Diego, United States Meet Full time

    Meet's partnered with an exciting and growing biotech in San Diego for a Senior Scientist / Principal Scientist Analytical Development!You'll be responsible for designing, executing, and reporting on the analytical development of small molecule chemistry experiments, degradation pathways, characterization, and stabilization techniques for ophthalmic and...


  • San Diego, United States Meet Full time

    Meet's partnered with an exciting and growing biotech in San Diego for a Senior Scientist / Principal Scientist Analytical Development!You'll be responsible for designing, executing, and reporting on the analytical development of small molecule chemistry experiments, degradation pathways, characterization, and stabilization techniques for ophthalmic and...


  • San Diego, United States Meet Full time

    Meet's partnered with an exciting and growing biotech in San Diego for a Senior Scientist / Principal Scientist Analytical Development!You'll be responsible for designing, executing, and reporting on the analytical development of small molecule chemistry experiments, degradation pathways, characterization, and stabilization techniques for ophthalmic and...


  • San Francisco, United States Amgen Full time

    **HOW MIGHT YOU DEFY IMAGINATION?** If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering...


  • San Diego, United States TCWGlobal Full time

    Job DescriptionJob DescriptionSr. Research Associate, Translational MedicineOnsite in San Diego, CA 92037Payrate: $30-$40/hrStart ASAP3-6 month AssignmentWeekly Pay and Benefits! Our leading biotech client, specializing in cell therapy, is seeking a driven and experienced Senior Research Associate. In this role, you will be a key contributor in the...


  • San Diego, United States TCWGlobal Full time

    Job DescriptionJob DescriptionSr. Research Associate, Translational MedicineOnsite in San Diego, CA 92037Payrate: $30-$40/hrStart ASAP3-6 month AssignmentWeekly Pay and Benefits!Our leading biotech client, specializing in cell therapy, is seeking a driven and experiencedSenior Research Associate.In this role, you will be a key contributor in the...


  • South San Francisco, United States SGA Inc. Full time

    Software Guidance & Assistance, Inc., (SGA), is searching for a Senior/Principal Scientist in Translational Medicine Mass Spectrometry for a CONTRACT assignment with one of our premier Pharmaceutical Services clients in San Francisco, CA. Responsibilities: ...