Senior Scientist II, Molecular Profiling and Drug Delivery

Found in: Resume Library US A2 - 1 week ago

North Chicago Illinois, United States AbbVie Full time
Job Description

The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state of the art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaboratively progress candidates with higher probability of success into development and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch, MPDD scientists work in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions. 

 

Drug Delivery scientists within AbbVie's MPDD organization work collaboratively with other functions within Development Sciences and Discovery to conduct developability assessment to select molecules with higher probability of success for clinical development and eventual commercialization.  This includes profiling of physicochemical properties, development of preclinical formulations, identifying solutions to in vivo absorption challenges, and advancement of novel drug delivery strategies across multiple routes of administration that are aligned with program target product profiles and downstream partners.  Modalities of interest include traditional small molecules as well as complex chemically synthesized modalities such as PROTACs and peptides.  In this role, you will work in cross-functional teams in matrixed environments and engage in multidisciplinary problem solving. 

 

Job Description 

 

AbbVie's MPDD organization is seeking a highly motivated, talented, and creative scientist with expertise and some experience in pharmaceutical sciences and drug delivery for a Senior Scientist II position.  The primary role of this position is to serve as an MPDD project leader on discovery programs, leading CMC developability assessment for emerging molecules on small molecule pipeline programs.  This role will also entail contributing towards developing our drug delivery capabilities with a focus on complex chemically synthesized modalities such as PROTACS and peptides.  This person will be working collaboratively with discovery and development partners across disciplines to improve delivery of these modalities and advance molecules to clinical development with improved developability profiles.  The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on developability, preclinical and/or clinical formulation, biopharmaceutics, and drug delivery concepts relevant to small molecules and peptides. 

 

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