Scientist II, Bioassay Development

4 weeks ago


South San Francisco California, United States AbbVie Full time
Job Description

The Bioassay Development group at AbbVie South San Francisco, CA is seeking a Scientist II to support the development and evaluation of newly discovered oncology and immunology drugs and existing clinical candidates. The selected candidate will join the Biologics Analytical Research and Development team, which has been involved in the development and IND submissions of 20+ novel biologic drugs and the successful filing of two BLAs. In this lab-based role, you will have unique and diverse exposure to drug development activities, numerous cross-functional interactions, and opportunities to grow and develop in your scientific career.

Responsibilities:

·Development and optimization of complex cell-based functional assays (bioassays) and target-binding potency assays critical for the development of therapeutic antibodies, antibody-drug conjugates (ADCs), multi-specific biologics, and novel/complex antibody variants.  

·Collaborate with Analytical Research and Development teams to elucidate structure/function molecular characterization and interact cross-functionally with teams from Discovery, CMC, QC, and more.

·Perform potency testing and characterization to support drug development activities and IND submissions.

·Qualify/validate/transfer potency methods to external partners and author technical documents (e.g. test methods, protocols, and reports) to enable regulatory submissions.

·Develop new techniques, explore new approaches and technologies, perform troubleshooting and optimization experiments, and present your work to various cross-functional teams.



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