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Scientist/Senior Scientist In Vitro Biology

2 weeks ago

Boston, Massachusetts, United States Atalanta Therapeutics Full time $120,000 - $180,000 per year

Position Summary:

Atalanta is seeking an experienced, highly
motivated, and detail-oriented molecular and cellular biologist to join our In
Vitro Biology team and lead the high-throughput screening team.  As
HTS team lead, this person will be responsible for the development and
expansion of our screening capabilities to evaluate siRNA efficacy in mammalian
cells and will oversee the implementation of HTS to support
preclinical drug development for multiple therapeutic targets.

Candidate
must be familiar with microplate-based cell culture and automated liquid
handling. A background in neurobiology and/or familiarity with neuronal cell
assay development is a plus. 

Essential
Functions:

·       
Implementing and optimizing high throughput
automated processes to accelerate siRNA compound screening and evaluation in
cell-based assays. 

·       
Developing and standardizing cell-based
assays, using skills in molecular cloning, stable cell line generation, cell
culture and expression analysis to assess biological activity of potential siRNA therapeutic
candidates

·       
Application of data analysis tools to assess
biological activity and assay performance and for statistical analysis of
experimental data

·       
Managing research associates in the
performance of screening assays, in a matrixed organization

·       
Interfacing with multiple project teams to
adapt assays to high throughput formats, stage and prioritize screens,
iteratively improve processes, and identify strong therapeutic lead compounds

·       
Communicating study designs, progress and
results through strong interpersonal interactions as well as slide presentations
and reports

 

Required Qualifications:

·       
Technical expertise in cell-based bioassays, high-throughput
screening automation, mRNA expression analysis and ELISA/multiplex assays.

·       
A strong background in assay development,
optimization and validation.

·       
Expertise in molecular biology, including
creation of stable cell lines for target evaluation

·       
A demonstrated ability to work with large
experimental data sets including statistical analyses.

·       
Experience in neurodegenerative and neurological
disease research

·       
Ability to work and think independently and
contribute as a part of a highly matrixed team

·       
Self-motivation, ability to multi-task, capacity
to handle multiple and changing priorities as well as fluctuations in the
workload

·       
Excellent organization skills and strong
attention to detail

·       
Outstanding problem-solving skills, ability to
independently analyze and present data to scientific teams, excellent
communication skills (oral and written)

 

Education

·       
Ph.D. in
neuroscience, biochemistry, or a relevant biological science with an additional
3+ years of relevant industry experience in assay development and high
throughput screening, or a B.S./M.S. with equivalent experience

 

 Please
submit your CV and cover letter to Reference job code S-KS

Atalanta is committed to equal
employment opportunity and non-discrimination for all employees and qualified
applicants without regard to a person's race, color, gender, age, religion,
national origin, ancestry, disability, veteran status, genetic information,
sexual orientation or any characteristic protected under applicable law.
Atalanta will make reasonable accommodations for qualified individuals with
known disabilities, in accordance with applicable law.