Scientist I/II, DMPK
20 hours ago
Monte Rosa Therapeutics (MRT) seeks to recruit an experienced, creative and highly talented DMPK and ADME Scientist who is eager will assit in leading the discovery and development effort to grow the drug pipelines, as well as help lead external GxP compliance research efforts. The Scientist will work MRTx colleagues to participate in all stages of DMPK and ADME assessments, from initial compound screening through to IND and NDA regulatory submissions. Working with Research, Bioanalytical and Clinical Science subject matter experts, provides scientific expertise to ensure that clinical candidates with acceptable drug development characteristics are identified and appropriately characterized. Represents Preclinical Development on Research and Development teams and regularly interfaces with internal and external colleagues to ensure timely and accurate dissemination of DMPK and ADME findings.
Responsibilities· Work closely with the medicinal chemistry team, the Scientist Position will facilitate the Nonclinical Development efforts in troubleshooting and guidance to the discovery project team with a particular focus on optimizing properties for oral administration · Represent Nonclinical Development to project teams and present our work in the interpretation of ADME experimental data related to the in vitro and in vivo animal PK and biotransformation. · Continually learn in vitro ADME and in vivo animal PK analysis (Winnolin) · Coordinate outsourced in vitro and in vivo DMPK studies · Explore new technologies and capabilities in discovery DMPK space · Strong written and oral communication to support internal communication of data, study reports and regulatory documentation. · Ability to work on multiple projects in a matrixed organizational structure · Aide the Nonclinical Development & Clinical Pharmacology team's activities across multiple project phases, including lead discovery, lead optimization, and regulatory filings.
Qualifications· PhD/MS 3+ years of drug discovery industry experience in Drug Metabolism, Pharmacokinetics, Pharmaceutical Chemistry, Toxicology, or a related scientific discipline. · Effective management of internal and external collaborations/service providers (CROs) · Build relationships with peers and partners outside of Nonclinical Development & Clinical Pharmacology to enable high team performance. · Demonstrates novel, innovative solutions to challenging problems using an extremely high degree of scientific discretion, intuition, and integrity. · Strong collaboration and innovative skills across subject areas representing DMPK as a project team representative within the core team is a key requirement. · Experience in the design, conduct, and interpretation of in vitro and in vivo ADME and animal PK studies. · Ability to work on site 100% is required
-
Scientist I
20 hours ago
Boston, Massachusetts, United States Dana-Farber Cancer Institute Full time $120,000 - $180,000 per yearThe Mancias Lab studies critical aspects of the biology of pancreatic cancer to develop novel therapeutic approaches. Areas of emphasis are on the role of selective autophagy and iron metabolism in pancreatic cancer molecular pathogenesis (Mancias et al., Nature 2014; Mancias et al., eLife 2015; Santana-Codina et al., Cancer Discovery 2022). We are also...
-
Senior Research Scientist, Cell Engagers
2 days ago
Boston, Massachusetts, United States iHire Full time $137,000 - $234,800 per yearTakeda Pharmaceutical has partnered with iHire to reach top talent for their opening below. Check it out and apply via iHireChemists todayBy clicking the Apply button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takedas Privacy Notice and...
-
Senior Scientist, Biologics Generation
3 days ago
Boston, Massachusetts, United States Takeda Full time $137,000 - $215,270 per yearBy clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job...
-
Managed Assets Portfolio Manager II
16 hours ago
Boston, Massachusetts, United States Eastern Bank Full timeJob DescriptionThe Portfolio Manager II is to assist and work collaboratively within the Managed Assets department to reduce the risk profile of the classified commercial credits. Additionally, the Portfolio Manager II shall mentor Portfolio Manager I and Credit Analyst.Manage monthly/quarterly reporting:Oversee and coordinate completion of Managed Asset...
-
Boston, Massachusetts, United States Commonwealth of Massachusetts Full time $75,950 per yearPosition Information:Position Title: Seasonal Environmental Analyst IILocation: Water ResourcesStart date: ASAPEnd date: 3/21/26Number of Positions: 1Please note, if you are selected for this position and will be working less than 90 days, the position will automatically revert to a short-term position. Our short-term positions are not part of the salary...
-
VP- Generative Chemistry
2 days ago
Boston, Massachusetts, United States Raven (RA Ventures) Full time $200,000 - $400,000 per yearAbout Raven:We are Raven, RA Capital's healthcare incubator. From discovery to delivery, whether we incubate, accelerate or rejuvenate, Raven's goal is to turn scientific breakthroughs into transformative therapies and get them quickly, safely and efficiently to the patients that need them most. Raven's experienced scientists, operators, and healthcare...
-
Life Enhancement Coordinator II
23 hours ago
Boston, Massachusetts, United States Hebrew SeniorLife Full time $52,000 - $79,370 per yearJob DescriptionI. Position Summary:Under direction of the Community Life Leader, the Life Enhancement Coordinator will demonstrate a strong commitment to the philosophy and goals of the mission of Hebrew Senior Life and recognize patient dignity and choice in aspects of daily life. Provide support and direction to the interdisciplinary team to meet all the...
-
Machine Learning Engineer II
3 days ago
Boston, Massachusetts, United States Chewy Full time $140,850 - $193,500Our Opportunity:We are looking for a Machine Learning Engineer II at our Boston, MA location to apply artificial intelligence and/or machine learning methods to design, test and scale effective, reliable frameworks, systems, and models to improve the usefulness of big data and predictive applications.What You'll Do: Research, implement, and test machine...
-
Boston, Massachusetts, United States Elektrofi Full time $104,000 - $157,500 per yearJob TypeFull-timeDescriptionABOUT ELEKTROFIElektrofi is revolutionizing the delivery of biologic therapies by giving patients the ability to control how they want to receive and benefit from life-changing medicines. Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated with intravenously administered...
-
Research Assistant II
3 days ago
Boston, Massachusetts, United States Wyss Institute at Harvard University Full time $60,000 - $90,000 per yearCompany DescriptionBy working at Harvard University, you join a vibrant community that advances Harvard's world-changing mission in meaningful ways, inspires innovation and collaboration, and builds skills and expertise. We are dedicated to creating a diverse and welcoming environment where everyone can thrive.Why join the Wyss Institute at Harvard...
