Associate Director of Antibody Engineering

3 days ago


San Diego, California, United States AlivaMab Discovery Services LLC Full time
Job Title: Associate Director, Antibody Engineering

AlivaMab Biologics is seeking an exceptional Associate Director of Antibody Engineering to lead our Antibody Engineering and Molecular Biology Team. This position will oversee a team of scientists responsible for designing, generating, and characterizing antibody-based therapeutics, including advanced modalities such as multispecifics and single-domain human VH antibodies.

Key Responsibilities:
  • Lead the development of a robust phage-based immune repertoire display platform for forced common light chain and single-domain human VH antibody discovery and optimization.
  • Design, lead, and execute engineering campaigns to deliver cutting-edge, developable biologics formats by applying molecular biology, phage display, combinatorial, structure-guided, and computational approaches.
  • Contribute to the expansion of antibody engineering capabilities and new technologies for antibody drug discovery.
  • Collaborate with leaders and teams across antibody discovery, protein sciences, and project management on project delivery and new technology development.
  • Generate precise technical summaries and maintain proper documentation for partner-facing external presentations.
  • Provide growth opportunities and career development support for staff, and carry out performance management/reviews for staff.
Requirements:
  • PhD in a relevant scientific area, such as antibody or protein engineering, protein biochemistry or biotechnology, plus a minimum of 8 years of professional experience in biologics research.
  • Deep understanding of diverse biologics formats, including multispecific antibodies, single-domain antibodies, ADCs, and other modalities.
  • Hands-on experience with antibody phage display platforms is required.
  • Experience with protein engineering to improve developability and affinity modulation is preferred.
  • Understanding NGS-based repertoire analysis is highly desired.
  • A background in structure-based antibody design and engineering is desired.
  • Excellent communicator and highly effective in interacting with key internal and external stakeholders.
  • Team player and builder, possess great coaching skills, and have great organizational skills.
  • High degree of professionalism and dedication to exceptional quality and integrity.

AlivaMab Biologics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

Salary range: $160,000 - $195,000


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