Neuroscience Bioinformatics Internship Opportunity

3 weeks ago


Cambridge, Massachusetts, United States AbbVie Full time

Internship Overview

AbbVie is seeking a highly motivated and skilled Bioinformatics for Neuroscience intern to join our team at the Genomics Research Center (GRC). As a member of our team, you will have the opportunity to work on a cutting-edge project focused on target identification for Alzheimer's Disease.

Project Description

The project will involve collecting and analyzing datasets, including microglia relevant variants from our internal eQTL study and microglia promoter-capture Hi-C from manuscript. You will also perform colocalization analysis under the assumption of more than one casual variant, filter variants that overlap with peaks in Hi-C, and identify risk genes associated with the promoters.

Responsibilities

  1. Collecting datasets: microglia relevant variants from our internal eQTL study and microglia promoter-capture Hi-C from manuscript
  2. Analysis: identify variants that are eQTLs, extending to disease specific or microglia subtype specific, and perform colocalization analysis under the assumption of more than one casual variant
  3. Analysis: filter variants that overlap with peaks in Hi-C and identify risk genes associated with the promoters
  4. Filtering: shortlist relevant genes by using information from other single-nuclei RNAseq and consortium studies
  5. Pitch: share results with Neuroscience stakeholders to do a deep dive on the prioritized targets and perform knock-out experiments in microglia to understand the biology and pathways involved

Qualifications

To be eligible for this internship, you must be currently enrolled in a university, pursuing a PhD in Bioinformatics, Computational Biology or other related field. You must also have knowledge in R or Python programming, strong written, verbal and oral communication skills, good self-organization, and strong quantitative and analytical skills.

Benefits

As an AbbVie intern, you will receive competitive pay, relocation support for eligible students, select wellness benefits, and paid holiday/sick time. You will also have the opportunity to connect with AbbVie leaders and scientists, and gain exposure to cutting-edge discovery concepts and technologies.



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