Senior Genomics Research Manager

1 month ago


South San Francisco, California, United States NewLimit Full time
NewLimit is a Biotechnology Company Revolutionizing Human Healthspan

We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells.

Job DescriptionFunctional Genomics Scientist with Leadership Experience

We're seeking a seasoned functional genomics scientist with leadership experience to lead our Functional Genomics team. Our team is focused on developing and deploying pooled screening methods to discover partial reprogramming targets.

Your role will involve improving the fidelity and scale of our methods, deploying them to new cell types, and reducing associated costs and turn-around times to optimize the number of discoveries we make per day, per dollar.

Key Responsibilities
  • Lead and recruit a team of scientists and research associates
  • Develop new functional genomics technology and execute production-scale reprogramming screens in collaboration with our Single Cell Technology and Predictive Modeling teams
  • Contribute to laboratory implementations and training at the bench
  • Develop methods for the construction, delivery, and control of partial reprogramming payloads in primary mammalian cells of diverse cell types
  • Contribute to company-wide decision making on indication selection, program prioritization, and resource allocation
Requirements
  • Ph.D. in molecular biology, cell biology, or a related field or equivalent industry experience (5+ years)
  • Experience leading a cross-functional team and managing direct reports
  • Experience with functional genomics approaches for arrayed or pooled screening (e.g. one of: CRISPR-Cas pooled fitness screens, gene expression perturbation profiling, CROP/Perturb-seq, or similar methods)
  • Experience with in vitro and in vivo transgenic delivery methods for mammalian cells (at least one of: lentivirus, AAV, AdV, transposition systems, CRISPR-Cas targeted editing, lipid nanoparticles, or similar)
Nice to Have
  • Therapeutics discovery and development experience
  • Experience with epigenetic reprogramming methods using transcription factors for cell fate engineering or CRISPR-Cas tools for targeted epigenetic editing
  • Experience working with primary cells and tissue samples
  • Experience with single cell genomics methods
  • Programming ability in one of: Python, R, Rust
Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) - 20 days/year for all employees + holidays
  • Meals and snacks on-site


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