Medicinal Chemistry Project Leader

1 week ago


New Haven, Connecticut, United States BioSpace, Inc. Full time
Job Summary

We are seeking a highly skilled Medicinal Chemistry Project Leader to join our team at Arvinas. As a key member of our neuroscience research team, you will be responsible for leading multiple target-oriented PROTAC projects to deliver milestone decisions in line with target project profiles and timelines.

Key Responsibilities
  • Effective team-oriented leadership of multiple target-oriented PROTAC projects to deliver milestone decisions in line with target project profiles and timelines
  • Expeditious molecular and synthetic design of PROTACs and libraries in conjunction with state-of-the-art computational chemistry resources to enable program advancement
  • Dynamic interaction with external CRO resources to ensure synthetic and PK/ADME data needs are fulfilled according to agreed timelines and standards
  • Solicitation and analysis of necessary experimentation/data to allow identification and prioritization of issues, and crisp decision making within the project environment to meet company, project and personal goals and timelines
  • Ensure that key program progression, compounds, and data are being generated and decision-making based on strong scientific judgment is occurring
  • Provide considered and focused input across all phases of drug discovery, collaborate effectively with other drug discovery functional areas, and exemplify leadership, demanding excellence in performance at all levels
  • Provide transparent, coherent, and focused updates to manager and company executives on request and represents company interests at conferences and in scientific matters to external organizations as needed
  • Contribute novel insights and analysis to further develop and evolve the PROTAC platform
Qualifications
  • Extensive knowledge of synthetic and medicinal chemistry-related scientific and technological principles to design and execute drug-discovery experiments on a project basis
  • Experience working in the neuroscience therapeutic area and/or on targeted protein degradation projects is preferred
  • Manages time and completes tasks in timely manner
  • Manages a group of external scientists
  • Maintains accountability for ensuring own goals, project team goals, and company objectives are met
  • Represents research project team at high level meetings within the company
  • Maintains orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Makes broad scientific contributions that have a positive impact on the research direction of the company
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents
  • A track record of creative contributions to drug design, especially optimizing pharmaceutical & DMPK properties and making critical scientific contributions at the project team level as a chemistry and/or project leader
  • Represents the company effectively in scientific matters to external organizations
  • A strong patent and publication record evidencing scientific curiosity and strong communication skills
  • Proficiency with database mining and multi-parameter optimization
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas
Education
  • A PhD medicinal chemist with 12+ years of pharma/biotech-based drug discovery experience, with a track-record of leading neuroscience research projects towards IND-track nomination

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity Employer



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