Research Scientist

4 weeks ago


Cambridge, Massachusetts, United States Moderna Theraputics Full time

Immunopeptidomics and Mass Spectrometry Expert

Moderna Therapeutics is seeking a talented and motivated Scientist to join our Cancer Vaccine Research team to support research efforts across discovery and pre-clinical initiatives.

The ideal candidate will have a background in the field of mass spectrometry-based proteomics, with extensive experience operating nano-liquid chromatography-mass spectrometry (nLC-MS) systems and expertise in data acquisition method generation.

This role requires understanding of instrumentation, sample processing, and data analysis workflows, as well as the ability to manage multiple projects in a fast-paced environment with aggressive timelines.

The successful candidate will be responsible for performing sample preparation, nLC-MS data acquisition, and data analysis and interpretation to aid in the discovery and validation of tumor-associated antigens and neoantigens.

Key Responsibilities:

  • Consistently update a lab notebook to ensure accurate documentation of experiments, observations, and results
  • Maintain up-to-date knowledge of literature in the field of proteomics, immunopeptidomics, and cancer vaccines
  • Collaborate with other research teams to integrate immunopeptidomics and proteomics data into their research areas
  • Contribute to the reviewing and writing of scientific manuscripts and IND reports
  • Present findings at internal meetings and represent Moderna at scientific conferences

Requirements:

  • Degree in Immunology, Biochemistry, Molecular Biology, or a related field
  • Extensive experience operating nano-liquid chromatography-mass spectrometry (nLC-MS) systems, with expertise in data acquisition method generation
  • Expertise with bioinformatics tools and software used for mass spectrometry data analysis
  • Ability to manage multiple projects in a fast-paced environment with aggressive timelines

Preferred Qualifications:

  • Hands-on experience with quantitative mass spectrometry assays
  • Familiarity with Bruker timsTOF instruments and PASEF data acquisition methods
  • Proficiency with the following software programs: R, Python, FragPipe, Spectronaut, and Skyline

What We Offer:

  • Competitive salary and benefits package
  • Opportunity to work with a leading mRNA technology platform
  • Collaborative and dynamic work environment
  • Professional development opportunities

About Moderna Therapeutics:

Moderna Therapeutics is a biotechnology company that is pioneering the use of mRNA technology to develop novel therapeutics. We are committed to advancing the field of mRNA technology and improving the lives of patients worldwide.


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