Research Scientist, Cell Engager Therapies In Vivo Pharmacologist
2 days ago
Takeda is a world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. As a Research Scientist, Cell Engager Therapies In Vivo Pharmacologist, you will be responsible for the discovery and development of novel therapeutics in the T cell engager space, supporting new and ongoing pipeline programs.
Key Responsibilities:- Develop animal models to test the biological efficacy of therapeutic agents for oncology indications.
- Design and execute in vivo efficacy models in xenograft and PDX models.
- Participate in analysis of in vivo studies to help establish PK / PD / efficacy relationships.
- Execute experiments with minimum supervision and deliver comprehensive high-quality data sets to enable decision-making.
- Interpret results of complex experiments.
- Prepare and present comprehensive technical or project reports and formal presentations.
- Maintain laboratory notebooks and follow laboratory practices in compliance.
- Demonstrate in-depth technical in vivo knowledge.
- MS with 4+ years' experience, or BS with 6+ years' of research experience in a lab setting working with animals.
- Experience in industry required, in animal facilities.
- Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft, and PDX models.
- Experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, PO, RO), and blood/tissue collection.
- Imaging experience is highly desirable.
- Experience culturing and maintaining human tumor cell lines and primary human cells, preferably T cells, with best practices in tissue culture is critical.
- Hands-on basic experience with multi-color flow cytometry, ELISA, MSD, and other standard cell-based and non-cell-based biochemical assays is desired.
- Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo, etc).
Takeda is a patient-focused company that inspires and empowers you to grow through life-changing work. We are transforming patient care through the development of novel specialty pharmaceuticals and best-in-class patient support programs. Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do.
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