Research Associate Scientist Investigative Toxicology

3 days ago


Boston, Massachusetts, United States Takeda Pharmaceutical Full time

Job Summary:

Takeda Pharmaceutical is seeking a highly motivated Research Associate Scientist to join our Global Investigative Toxicology team. As a key member of our team, you will contribute to the detection and de-risking of toxicity in our portfolio to help make medicines safer and more effective.

Key Responsibilities:

  • Design and implement early safety assessment screening strategies to enable the progression of optimized therapeutic candidates.
  • Conduct cell-based in vitro assays to characterize immune-mediated toxicities for medicines in discovery & development.
  • Develop novel in vitro model systems to assess safety risks associated with new therapeutic designs.
  • Maintain cultures of immortalized tumor cell lines, primary cell types of various origin, and primary immune cells.
  • Perform fit-for-purpose ex vivo analyses to assess phenotypic and functional correlates of toxicity.
  • Prepare experimental protocols, analyze experimental data, and present study results in team and department meetings.
  • Contribute ideas to drive innovation within investigative toxicology and with key collaborators.

Requirements:

  • MS. with 3+ years or BS with 5+ years of experience in immunology, biology, biochemistry, pharmacology, or a related discipline.
  • Expert with standard aseptic cell culture technique, including experience culturing various tumor cell lines and primary cells.
  • Broad experience with cell-based functional assays, including cytotoxicity, cytokine release, and proliferation assays.
  • Basic experience with molecular biology techniques including RNA/DNA extraction, qPCR, western blot.
  • Experience working in a matrixed team environment at a pharmaceutical company and/or CRO.
  • Broad scientific knowledge in immunology and pharmacology.
  • Self-motivated with strong time management and organizational skills.
  • Ability to balance multiple projects and flexible with changing priorities.
  • Highly collaborative with demonstrated ability to work in a matrixed team environment.
  • Excellent oral and written communication skills.

What We Offer:

  • Competitive salary range: $96,000 - $151,800.
  • Short-term and long-term incentives.
  • Medical, dental, vision insurance.
  • 401(k) plan and company match.
  • Short-term and long-term disability coverage.
  • Basic life insurance.
  • Tuition reimbursement program.
  • Paid volunteer time off.
  • Company holidays.
  • Well-being benefits.

Equal Employment Opportunity:

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.



  • Boston, Massachusetts, United States Takeda Pharmaceutical Full time

    About the Role:Takeda Pharmaceutical is seeking a highly skilled Research Scientist I, OEPQT to join our Occupational, Environmental and Product Quality Toxicology team. As a key member of our team, you will be responsible for providing toxicology risk assessments to support Takeda's Environmental Health and Safety (EHS) and pharmaceutical manufacturing...

  • Research Scientist

    3 weeks ago


    Boston, Massachusetts, United States Tufts University Full time

    Job SummaryWe are seeking a highly motivated Research Associate to join our team at Tufts University. The successful candidate will work under the supervision of the principal investigator and in cooperation with other lab members and senior scientists in neighboring labs.Key ResponsibilitiesThe Research Associate will design and conduct experiments using a...

  • Research Scientist

    3 weeks ago


    Boston, Massachusetts, United States Mass General Brigham Full time

    Job Title: Research ScientistWe are seeking a highly motivated and experienced Research Scientist to join our team at the Massachusetts General Hospital. The successful candidate will be responsible for designing, planning, and executing cell-based, biochemical, and in vivo experiments to validate candidate disease genes and assess gene function.Key...


  • Boston, Massachusetts, United States PepGen Full time

    Job OverviewPepGen is seeking a highly skilled and innovative Senior Research Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. The successful candidate will be primarily responsible for the key aspects of the research and development, including pharmacology, of PepGen's Enhanced Delivery Oligonucleotide (EDO)...

  • Research Scientist

    2 days ago


    Boston, Massachusetts, United States Tufts University Full time

    Job SummaryThe Research Associate will work under the supervision of the principal investigator and in cooperation with other lab members and senior scientists in neighboring labs. The successful candidate will design and conduct experiments using a variety of skills, including microscopy, live cell imaging, quantitative cell biology, molecular biology,...


  • Boston, Massachusetts, United States PepGen Full time

    Job OpportunityPepGen is seeking a highly skilled and innovative Principal Scientist to join our Preclinical Research and Development team in Boston, Massachusetts. As a key member of our team, you will be responsible for leading the development, optimization, and execution of in vitro and in vivo nonclinical pharmacology studies.Key...


  • Boston, Massachusetts, United States Mass General Brigham Full time

    Job Title: Research Lab Tech IIJob Summary:The Research Lab Tech II position involves conducting research and administrative tasks in a laboratory setting. Under the supervision of the Principal Investigator, the Research Lab Tech II will conduct independent and collaborative research involving molecular biology and microbiology techniques.Key...

  • Research Scientist

    4 weeks ago


    Boston, Massachusetts, United States Integrated Resources, Inc Full time

    Job Title: Associate ScientistWe are seeking a highly motivated Associate Scientist to join our research team at Integrated Resources, Inc. in Boston, MA.Job Summary:The successful candidate will be responsible for designing and implementing various in vitro cellular assays, executing high throughput compound and biologics screens, and developing...


  • Boston, Massachusetts, United States Eden GeoPower Full time

    Company OverviewEden GeoPower Inc. is a pioneering company developing innovative electro-hydraulic fracturing technologies to enhance subsurface resource recovery. Our mission is to create sustainable electric stimulation methods that minimize water use, underground water contamination, wastewater production, air pollution, and induced seismicity associated...


  • Boston, Massachusetts, United States Unreal Gigs Full time

    Job OverviewWe're seeking a highly skilled AI Research Scientist to join our team at Unreal Gigs. As a key member of our research team, you will be responsible for designing and developing innovative deep learning algorithms and architectures that push the boundaries of current AI capabilities.Your primary focus will be on conducting cutting-edge research in...


  • Boston, Massachusetts, United States Eden GeoPower Full time

    Company OverviewEden GeoPower Inc. is a pioneering company developing innovative electro-hydraulic fracturing technologies to enhance subsurface resource recovery. Our mission is to create sustainable electric stimulation methods that minimize water use, underground water contamination, wastewater production, air pollution, and induced seismicity associated...

  • Research Scientist

    3 days ago


    Boston, Massachusetts, United States Massachusetts General Hospital Full time

    Research Scientist Position at Massachusetts General HospitalWe are seeking a highly skilled and motivated Research Scientist to join our team at Massachusetts General Hospital. As a key member of our research team, you will play a vital role in advancing our mission to improve the health and well-being of pregnant and lactating individuals.Key...

  • Research Scientist II

    4 weeks ago


    Boston, Massachusetts, United States Mass General Brigham Full time

    Job Title: Research Lab Tech IIJob Summary:The Research Lab Tech II position involves conducting research and administrative tasks in a laboratory setting. Under the supervision of the Principal Investigator, the Research Lab Tech II will conduct independent and collaborative research involving molecular biology and microbiology techniques.Key...


  • Boston, Massachusetts, United States Brigham and Women's Hospital Full time

    Research Investigator OpportunityThe Division of Transplant Surgery at Brigham and Women's Hospital is seeking a highly qualified PhD research investigator with expertise in molecular and cellular biology in immunology, aging, or related fields, to work on clinical and experimental transplantation projects.Key Responsibilities:Conduct research on organ...


  • Boston, Massachusetts, United States Eden GeoPower Full time

    Company OverviewEden GeoPower Inc. is a pioneering company developing innovative electro-hydraulic fracturing technologies to enhance subsurface resource recovery. Our mission is to create sustainable electric stimulation methods that minimize water use, underground water contamination, wastewater production, air pollution, and induced seismicity associated...

  • Research Scientist

    4 weeks ago


    Boston, Massachusetts, United States Mass General Brigham Full time

    Postdoctoral Research Position in Artificial IntelligenceWe are seeking a highly motivated postdoctoral researcher to join our team at the Harvard Ophthalmology Artificial Intelligence (AI) Lab. The successful candidate will work under the supervision of Dr. Mengyu Wang at the Schepens Eye Research Institute of Massachusetts Eye and Ear and Harvard Medical...


  • Boston, Massachusetts, United States Brigham and Women's Hospital Full time

    Research Investigator OpportunityWe are seeking a highly qualified PhD research investigator with expertise in molecular and cellular biology in immunology, aging, or related fields, to work on clinical and experimental transplantation projects.Key Responsibilities:Conduct research on organ rejuvenation, perfusion/preservation, and...


  • Boston, Massachusetts, United States Brigham and Women's Hospital Full time

    Research Investigator OpportunityWe are seeking a highly qualified PhD research investigator with expertise in molecular and cellular biology in immunology, aging, or related fields, to work on clinical and experimental transplantation projects.Key ResponsibilitiesLead and support ongoing research projects, including the preparation of manuscripts and grant...


  • Boston, Massachusetts, United States Takeda Pharmaceutical Full time

    Research Scientist - In Vivo PharmacologyWe are seeking a highly skilled Research Scientist to join our In Vivo Pharmacology team at Takeda Pharmaceutical. As a key member of our team, you will be responsible for the discovery and development of novel therapeutics in the T cell engager space.Key Responsibilities:Develop and validate in vivo models of...


  • Boston, Massachusetts, United States Northeastern University Full time

    About the OpportunityThe College of Social Sciences and Humanities at Northeastern University is seeking a highly skilled Associate Data Scientist to support the National Internet Observatory, a research project funded by the National Science Foundation.The successful candidate will have a background in Computer Science, Data Science, or Statistics, with a...