Senior Principal Scientist, Leads Discovery and Optimization/Cellular Technologies Group

2 days ago

Princeton, New Jersey, United States Bristol-Myers Squibb Company Full time
About the Role

Bristol Myers Squibb is seeking a highly motivated and innovative Senior Principal Scientist to lead our Cellular Technologies Group. This prominent leadership position ensures the continuous supply of cultured and primary cells, organoids, and induced pluripotent stem cells (iPSCs) to support high-throughput screening activities and daily lead optimization assays.

Key Responsibilities
  • Plan, execute, and direct mammalian cell culture operations, including the development and application of iPSCs, organoids, and other complex cellular models.
  • Oversee a complex operation, managing a team of six scientists by assigning roles and responsibilities to ensure the delivery of cellular reagents required for efficient drug discovery operations.
  • Collaborate effectively across Bristol Myers Squibb's many research locations and work closely with our partner in India to produce a variety of cell-based reagents supporting experimental activities in the United States.
Requirements
  • Extensive experience and command of the principles of mammalian cell culture and proven managerial success in enacting these principles in an industrial setting.
  • Experience with automated cell culturing systems, such as the SelecT/CompacT, would be considered a plus.
  • Command of various primary cell isolation/differentiation and purification methodologies.
  • Significant experience in the maintenance, expansion, and differentiation of iPSCs to support genetic model development and phenotypic screens.
  • Extensive experience with the MaxCyte system to produce HTS quantities of transiently transfected cells.
  • Experience with lentiviral transduction and production of engineered human T cells.
  • Strong analytical and data analysis skills.
  • Ability to manage projects across functional lines and geographic locations.
  • Strong written and verbal communication skills for presenting data and ideas to multiple stakeholders across disciplines.
  • Ability to teach and train new entry-level scientists.
Preferred Qualifications
  • PhD in Molecular/Cellular Biology, Biochemistry, Bioengineering, or related field, with 4+ years' experience, and demonstrated expertise in the management of complex cell culture operations.
  • Experience in supporting the development of complex biological disease-related cellular models by providing differentiated iPSCs.
  • Experience applying laboratory automation to mammalian cell culture.
  • Knowledge of how CRISPR-engineered cell lines are developed.
  • Demonstrated excellence in written and oral communication.
  • Strong desire to succeed in cross-functional teams and collaborate in a highly matrixed environment.
About Bristol Myers Squibb

Bristol Myers Squibb is a global biopharmaceutical company dedicated to transforming patients' lives through science. Our unique culture promotes diversity, inclusion, and innovation, and we offer a wide range of competitive benefits, services, and programs that support our employees' well-being and career growth.

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