Therapeutic Discovery Leader
3 weeks ago
We are seeking a highly experienced Therapeutic Discovery Leader to join our team at insitro. As a key member of our leadership team, you will be responsible for guiding our molecular strategies and preclinical drug discovery efforts, leveraging advanced machine learning capabilities to drive success and accelerate our programs.
Key Responsibilities- Oversee multi-modality therapeutic discovery, leading a team of drug discovery professionals in areas including medicinal chemistry, DNA-encoded chemical library design, synthesis, and screening, complex biologics, oligonucleotides, analytical sciences, PKDM, protein sciences, and structural biology.
- Partner with Therapeutic Areas, Technical Operations, Preclinical & Clinical Development to develop indication strategies.
- Support drug discovery project teams to advance internal therapeutic leads and backups into IND-enabling studies and FIH trials.
- Engage with Pharma, Biotech, and provider partners to prosecute collaborative drug-discovery programs.
- Guide strategy on molecular design and technology, collaborating with diverse teams, including machine learning scientists, bioinformaticians, and statisticians, to develop advanced capabilities that can replace laboratory experimentation with modeling and simulation.
- Identify and access/internalize relevant technologies that can accelerate drug discovery and translational success.
- Foster collaborations with external partners, key opinion leaders, and academic institutions to enhance our scientific knowledge.
- Collaborate on company strategy and communications, providing scientific leadership and strategic input across all stages of drug development, from target identification to post-marketing activities.
- Work with other company leaders to guide our corporate strategy, bringing in perspectives on therapeutic modalities, tractability of drug development, and manufacturing strategies.
- Partner with Corporate Development and Strategy on new partnership plans and in-licensing/out-licensing activities.
- Communicate our clinical strategy and progress to stakeholders, including the board of directors, investors, and regulatory agencies.
We are looking for a highly experienced and skilled individual with a strong background in therapeutic discovery, preferably with a graduate degree in a relevant molecular discipline. You should have at least 15 years of experience in the pharmaceutical or biotechnology industry, with a record of successful early development candidates. You should also have deep experience in the discovery and early development of either small molecule or biologic therapeutics, with a desire to become fluent in additional modalities, particularly oligonucleotides.
You should have played a role in the design and execution of multiple drug discovery programs, ideally across more than one therapeutic area relevant to insitro (oncology, neuroscience, metabolic disease). Experience with multiple therapeutic modalities, a strong foundation in all aspects of synthetic drug discovery, and an interest in and exposure to the latest computational and data science methods are also essential.
You should have a quantitative mindset, a history of collecting and using data in clinical development, and a track record in building a high-performance team, with experience at the executive level. You should be able to work across departments and with colleagues from very diverse backgrounds, and have an attitude consistent with a small startup environment, including urgency, effort, and the desire for success.
You should be able to explain complex medical and scientific concepts to diverse audiences, and have demonstrated strategic thinking and a visionary approach to medical leadership in the context of AI-driven drug development.
What We OfferWe offer a competitive salary range of $300,000.00 - $360,000.00, as well as participation in our Annual Performance Bonus Plan and Equity Incentive Plan. We also provide excellent medical, dental, and vision coverage, a 401(k) plan with employer matching, open and flexible vacation policy, paid parental leave, quarterly budget for books and online courses, support to attend professional conferences, new hire stipend for home office setup, monthly cell phone and internet stipend, access to free onsite baristas and cafe, access to free onsite fitness center, and commuter benefits.
We are an equal opportunity employer and welcome applications from diverse candidates. We believe diversity, equity, and inclusion need to be at the foundation of our culture, and we work to bring together diverse teams-grounded in different expertise and life experiences-and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices.
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