Principal Scientist

3 weeks ago


Richmond, Virginia, United States Phlow Corporation Full time
Job Title: Principal Scientist

Phlow Corporation is seeking a highly skilled Principal Scientist to join our team. As a key member of our process development team, you will be responsible for developing and implementing synthetic routes for drug substances.

Key Responsibilities:

  • Design, synthesize, and purify chemical intermediates, target compounds, and impurities.
  • Provide process chemistry support to our Continuous Manufacturing R&D lab to ensure timely and budget-friendly deliverables to customer projects.
  • Maintain accurate and complete records of all experiments and observations.
  • Author progress reports and present scientific results to team members.
  • Ensure a high level of safety awareness and conduct lab operations in a safe manner.
  • Contribute to the timely and accurate preparation of regulatory submissions.
  • Collaborate with Analytical Chemistry, EH&S, Engineering, Project Management, Quality Assurance, and Regulatory Affairs to ensure strong working relationships with all partners and Phlow employees.

Requirements:

  • Ph.D. with a minimum 3 years of experience, M.S. with a minimum 7 years of experience, or B.S. degree with a minimum 10 years of experience in Organic Chemistry, Pharmaceutical Sciences, or a related scientific field.
  • Process chemistry and API manufacturing experience on multi-kilogram scale.
  • Knowledge of ICH and cGMP requirements.
  • Experience working for a contract organization (CROs/CMOs/CDMOs) is a plus.
  • Experience with technical and operational risk assessments (e.g., process robustness, mutagenic impurities, nitrosamines, etc.) is a plus.
  • Experience with design of experiments (DOE) and related multivariate experimentation approaches is a plus.
  • Experience with the development and implementation of continuous flow manufacturing processes is a plus.

Physical Requirements:

  • Constantly required to see to utilize computer screens and monitors to perform job duties including reading & writing, as well as when presenting information and communicating with others.
  • Frequently required to talk or hear to communicate with employees, candidates, vendors, and others, including presenting information in front of groups.
  • Frequently required to reach with arms and hands performing repetitive motions and using finger dexterity to work primarily at a computer keyboard and with a mouse.
  • Frequently required to sit, and occasionally required to stand or walk to move around primarily in an office environment.
  • Occasionally lift and/or move up to 10 pounds.

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